The Journal of Clinical Investigation’s Post

The sortilin-related receptor, SORL1, might play a pivotal role in fueling tau aggregation in glial cells. In a groundbreaking study led by Bradley Hyman and Dudley Strickland, scientists uncovered that SORL1 binds tau and co-localizes with it in neuroglioma cells. 💡 Moreover, manipulating SORL1 levels impacted tau seeding, shedding light on its potential involvement in Alzheimer's pathology. 🔍 Read the full article now on Alzforum and stay ahead of the curve in Alzheimer's research. - https://bit.ly/4ahHGtf #ADPD2025 #ADPD2024 #alzheimers #parkinsons #dementia #endalz #neuroscience #neuroscientist #researcher

Glad to share that our article "The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice" is now available in the public domain. This study showcase the potentials of small heterocyclic moieties for the management of Alzheimer's disease. #research #neuroscience #alzheimersdisease #drugdevelopment Here is the free access link for the complete article https://lnkd.in/g5Batrsz

📢 Original article Sharing-Vol. 23 No. 6 💕 Title: Antiepileptic and Neuroprotective Effects of Rheum tanguticum Root Extract on Trimethyltin-Induced Epilepsy and Neurodegeneration: In Vivo and in Silico Analyses 🤵 Authors: Jae-young Choi,†, Sohi Kang,†, Minh Nhat Tran, Sanghun Lee, Seung Mok Ryu, Sung-Wook Chae, Do-Hyun Kim, Ye Eun Lee, Sohee Jeong, Changjong Moon, Joong Sun Kim,*, Soong-In Lee,* 🔔 Full Text: https://lnkd.in/gu9utsct 🔑 Keywords: neurodegenerative disorders; inflammation; epilepsy; Rheum tanguticum; network pharmacology; 😎Welcome to your reading! #Parkinsons #ParkinsonsDisease #Neurology #BrainHealth #MovementDisorders #Dopamine #NeurodegenerativeDiseases #Healthcare #Research #Awareness #Treatment #SupportGroups #PatientCare #Therapeutics #MentalHealth #Neuroscience #CureParkinsons #BrainMapping #Neurobiology #BrainInjury #NeuroscienceNews #NeuroImaging

One of the first experiments you may perform with ioOligodendroyte-like cells™ is ICC, to check cell morphology and confirm the expression of key myelin-associated markers like MBP within 8 days post-thaw. We have just published a freely available ICC protocol for our ioOligodendrocyte-like cells. By making this standard experiment as easy as possible, you won’t have to spend time planning, helping you to confirm that these cells will work in your next assay in a matter of days. Read the protocol now: https://lnkd.in/eusZGXfc #research #DrugDiscovery #MultipleSclerosis #msresearch #neurology #neuroscience #glia #iPSC #leukodystrophy #neurodegeneration #screening #optiox #ioCells #data

New research has shed light on the physiological role of S129P alpha-synuclein in neuronal activity. The study found that blocking Ser129P prevents activity-dependent synaptic attenuation by α-syn, which is thought to reflect its normal function. Interestingly, the authors also discovered that neuronal activity actually augments Ser129P, which functions as a trigger for protein-protein interactions necessary for mediating α-syn function at the synapse. Check out the full article for more details: https://lnkd.in/e4SSjjGw. #neuroscience #research #synapse #physiology

The moonshot is a fundamental array of new therapeutics. Is monepantel going to be part of this moonshot approach? Can monepantel address one of the underlying mechanism of ALS - dysfunctional autophagy? Follow #PharmAust on its journey to tackle this hideous disease front on. #ALS #ALSStrong #ALSAwareness #MNDAustralia #FightMND #Biotech #Science #Neuroscience #NeurodegenerativeDiseases

🧬📚 "Epigenetic alterations in creatine transporter deficiency: a new marker for dodecyl creatine ester therapeutic efficacy monitoring" – our latest research published in Frontiers in Neuroscience offers exciting insights into the epigenetic mechanisms underlying creatine transporter deficiency (CTD). 🔍🧠 We discovered that deficient creatine uptake in CTD leads to hypo-methylation of nucleic acids in both Slc6a8 knockout mouse models and brain organoids derived from CTD patients' cells. 🐁🧫 Remarkably, treatment with dodecyl creatine ester (DCE), a promising prodrug, showed potential in restoring normal levels of DNA methylation in vivo. 💊🔬 This groundbreaking finding suggests that DNA methylation could serve as a marker to monitor the efficacy of DCE treatment in CTD patients, paving the way for personalized medicine approaches. 🎯👨⚕️ 🔗 Read the full article: https://lnkd.in/dRRjtJ2y #Epigenetics #Neuroscience #CreatineDeficiency

We are excited to share an article from Science Magazine confirming the power of Sangamo’s zinc fingers for editing in the brain, click here to view it, bit.ly/3W2Apd9. The authors demonstrate that Sangamo's previously published prion zinc fingers were superior to other platforms and enabled Neumann et al to test their new epigenetic editing tool. We are proud to have pioneered the zinc finger technology that continues to lead the field of epigenetic editing. These compact, flexible tools can precisely target DNA, enhancing our potential therapies for neurological diseases including prion disease. Our zinc finger-based prion program, ST-504, is advancing towards the clinic enabled by our proprietary STAC-BBB capsid. Learn more about our whole brain delivery solution by clicking on the links below. Whole brain delivery solution, https://bit.ly/3tH18AH STAC-504, https://bit.ly/3RLFpjI STAC-BBB, https://bit.ly/3xKCWiz #GenomicMedicine #neurology #zincfinger #prion

Here is a wonderful advance in neuroscience research that will likely lead to significant therapeutic advances in management of neurodegenerative diseases! Congratulations are well deserved for this discovery by Xiaolu Yang, PhD along with his team at Perelman School of Medicine at U. of PA. #neurodegeneration #neurosciences #biotechnology #pharmaceutical

Call for Papers - Special Issue: Emerging Practices in Therapeutic Targeting of Neurodegenerative Diseases by Modulating Protein Kinases Journal: Brain Research We invite researchers and experts to contribute to our upcoming special issue focused on innovative approaches in therapeutic targeting of neurodegenerative diseases through the modulation of protein kinases. Submissions exploring novel insights, experimental findings, and clinical applications are welcomed. More detail on topic and submission guidelines are provided below.. Co-Editor: Prof Belgin Sever #brainhealth #neuroscience #neurodegenerativediseases #médecine #pharmaceuticals #drugdiscovery #cellandgenetherapy #therapeutics #diagnostics #drugdevelopment https://lnkd.in/gPzDPCmF