Kedrion Biopharma’s Post

#breastcancer screening is an area we would love to see more #femtec #founders get in to, especially to decrease #disparities. “When Black women are diagnosed, it tends to be at a later stage of the disease. White women are diagnosed with stage 1 and 2 and Black women more often at stage 3 or stage 4, which is metastatic,” Lisa Hayes, ED for Pink-4-Ever, Inc said. Here are some areas for improvement: 1. A recent study showed that "although most women reported that their clinicians counseled them about breast density, the unaddressed worries or concerns and unanswered questions, especially among Hispanic and Asian women and those with low literacy, highlighted areas where discussions could be improved." This would be an easy patient education module. 2. Self scheduling can vastly improve our screening rates. "“Self-scheduling helps make the path to mammogram completion a little smoother” said the study’s lead author, Kimberly Waddell, PhD, MSCI. “Simple changes like these can have an outsized impact on preventive health screenings.” 3. Patient navigators can help with follow up tests needed to assess for cancer, especially for patients with low resources. The study concluded that "Expanding patient navigators to include all disadvantaged women within primary care networks could improve equity in cancer care." What are your ideas? What are you working on? Sources: Intro: https://lnkd.in/etKhHTfp 1. Kressin NR, Wormwood JB, Battaglia TA, Slanetz PJ, Gunn CM. Sociodemographic Variations in Women’s Reports of Discussions With Clinicians About Breast Density. JAMA Netw Open. 2023;6(11):e2344850. doi:10.1001/jamanetworkopen.2023.44850 2. https://lnkd.in/eKUES7zy 3. https://lnkd.in/ey7gzKzg

Chiesi Group and Oak Hill Bio have announced that the first patient has enrolled for the resumed Phase 2b clinical study evaluating OHB-607 for the potential prevention of Bronchopulmonary Dysplasia, the most common cause of Chronic Lung Disease in premature infants. This is a significant advancement in the shared mission of our companies with a treatment that has the potential to be the first innovative respiratory therapeutic advance for extremely preterm neonates in over thirty years. Diego Ardigò, Global Research & Development Head at Chiesi Group, comments on this new clinical trial and the company’s commitment to advancing neonatology. Read more here: https://lnkd.in/grBwSU5D #Chiesi_USA #Respiratory #Neonatology #Partnership #ClinicalStudy 

Alopecia areata (AA) is known to impact the health-related quality of life (HRQoL) of affected individuals, yet there is a paucity of research focusing on its effects specifically in pediatric patients and their families. To address this gap, researchers recently conducted a single-center cross-sectional cohort study aimed at assessing the HRQoL of pediatric patients diagnosed with AA and evaluating its impact on their parents. Read on here: https://bit.ly/49TlBkH

📢 Research Update: The Impact of Triumf Mobile Health Game on Pediatric Cancer Patients Triin Tark's master's thesis, "The Effect of Triumf Mobile Health Game on Psychological Well-Being and Health-Related Quality of Life Among Pediatric Cancer Patients: A Pilot Study," offers significant insights into the benefits of our gamified digital health intervention. 🧒 Study Overview: Children with chronic illnesses, such as cancer, are at a higher risk of developing mental health issues and often lack adequate psychological support. Triumf's mobile solution Triumfland Saga aims to detect, prevent, and reduce these psychological challenges through a gamified approach. 🔍 Research Highlights: Participants: Nine pediatric cancer patients aged 7-12 years. Intervention: 60-day period with a recommended 10 minutes of gameplay daily. Measurements: Strengths and Difficulties Questionnaire (SDQ) and KIDSCREEN-52 (KS-52) were completed by participants and their parents before and after the intervention. 📈 Key Findings: Improved Psychological Well-Being: Participants showed significant improvement in psychological well-being post-intervention. Enhanced Physical Health: The KS-52 physical health subscale score indicated better overall health-related quality of life (HRQoL). Partial Support for Intervention Questions: The study found partial support that intervention questions could detect similar issues as standardized questionnaires. The findings suggest that Triumf's digital intervention, in the form of a mobile health game, can positively impact the psychological well-being of pediatric cancer patients. Further research is recommended to explore its effects on other populations and to validate the intervention questions. This study highlights the potential of digital health solutions in providing essential psychological support to children with chronic illnesses. 🌟 #DigitalHealth #PediatricCare #MentalHealth #GamifiedHealth #HealthcareInnovation #TriumfHealth #teamtriumf #TriumflandSaga Read the thesis: https://lnkd.in/gWAjFxB4

A Paediatric Brain Tumor is an abnormal growth of cells in the brain that may be benign (non-cancerous) or malignant (cancerous). Early detection and treatment are vital for better outcomes. Symptoms can include persistent headaches, morning nausea and vomiting, vision problems (such as double vision or vision loss), balance and coordination issues, seizures, unexplained weight changes, behavioral shifts, and difficulties with speech, hearing, or memory. If your child exhibits any of these symptoms, seek medical advice promptly. At Dharan Cancer Specialty Centre, we offer comprehensive screening and advanced treatment options for Brain tumors in children. Our expert team utilizes state-of-the-art diagnostic tools and personalized treatment plans to ensure the best possible care for your child. From precise imaging techniques to innovative surgical and non-surgical treatments, we are dedicated to providing compassionate and effective care. If your child exhibits any symptoms of a Brain Tumor, book a consultation with our specialists for comprehensive screening and ensure their health and safety. #DharanHospital #braincancertreatment #tumor #PediatricBrainTumor #screeningforbraintumor #Braincancersymptoms #cancertreatment #cancerpatients #cancercare #cancercentre #comprehensivecancercare #braincancer #braintumor #BrainAwareness For Further Query #Call : +91 - 99439 39990 #Visit : https://lnkd.in/fqCzSnA

Preventing brain damage in preterm babies When babies are born extremely prematurely, the tiny and fragile blood vessels in their brain can break, causing a hemorrhage; the younger the baby, the higher the risk. Why this happens is not fully known, but poor neurological outcomes from brain bleeding are well established, explains the senior author. In the new study, scientists demonstrated in mouse models that fibrin, which normally works to enable blood clotting, interferes with a cell-signaling pathway that plays a vital role in neuron creation—particularly in the cerebellum. They also confirmed their findings using brain scans from nearly 60 preterm infants. No other blood protein had the same inhibitory effect on this pathway, the author says, which allowed the team to pinpoint fibrin as a clear therapeutic target for treating babies who experience brain bleeds. The study’s findings hold great significance for neonatal care, but also expand into other realms of medicine, as the signaling pathway (known as the “sonic hedgehog” pathway, or SHH) at the center of the study plays other important roles in human development and is implicated in a wide range of diseases. The lab previously developed a drug, a therapeutic monoclonal antibody, that acts only on fibrin’s harmful properties without affecting its beneficial role in blood clotting. This fibrin-targeting immunotherapy protects from multiple sclerosis and Alzheimer’s disease in mice. A humanized version of this first-in-class fibrin immunotherapy is already in Phase 1 safety clinical trials by Therini Bio. #ScienceMission #sciencenewshighlights https://lnkd.in/gku24vTY

Today, as we mark International #RareDiseaseDay, I would like to remind the staggering reality: over 200 million children worldwide grapple with rare diseases. At Pierre Fabre Laboratories, we stand committed to making a tangible difference in their lives. We believe in action that illustrate our dedication. 👉 Collaborating with EspeRare foundation, we're pioneering an innovative in-utero therapy, a real hope for young patients battling XLHED. This rare genetic disorder, impacting 500 infants annually, affects not just their sweat glands, skin and hair, but also their teeth. 👉 In the realm of oncology, our alliance with Atara Biotherapeutics has led to a major step forward in treating EBV+ PTLD, a rare post-transplant lymphoma. Approved by the EMA, this treatment, honored with the 2023 Prix Galien France 🏆, is a lifeline for numerous children. 👉 Teaming up with Bordeaux University Hospital, we've developed a revolutionary drug to manage infantile hemangiomas, a benign tumor that afflicts 4.5% of infants under one year old, offering them a brighter, healthier future. 👉 Through our partnership with Association Ichtyose France and patient associations, we're tirelessly gathering crucial data to enhance the lives of those affected by ichthyosis, a debilitating skin disorder impacting around 1% of individuals and profoundly affecting their quality of life. Together, let's amplify our efforts in the battle against rare pediatric diseases! 💪 https://lnkd.in/dhm3Ypg9 cc. Nuria Perez Cullell #PierreFabre #RareDiseases #Medical #Innovation #NewWaysToCare #Pediatry

💛 Being a parent of a child with #retinoblastoma, living with its effects, or caring for patients can be incredibly challenging. Focusing on our year-long theme of #EarlyDiagnosis, we explore some of the obstacles in the retinoblastoma community and share three ways we can work together to improve care for everyone. Read more in our latest blog post: #ChildhoodCancer #EarlyDetection #Healthcare #PatientCare #ChildrensHealth #ChildhoodCancerResearch #PediatricOncology #IntegrativeOncology #Oncology #Pediatrics https://lnkd.in/gdDJ6YGW

🌟 "Heart Transplantation in Children With Down Syndrome" 🩺 Authors: Justin Godown, MD, FAHA, darlene fountain, Neha Bansal, Rebecca Ameduri, Susan Anderson, Gary Beasley, Danielle Burstein, Kenneth Knecht, Kimberly Molina, SHERRY PYE, Marc Richmond, Joseph A Spinner, Kae Watanabe, Shawn West, Zdenka Reinhardt, Janet Scheel, Simon Urschel, Chet Villa, Seth Hollander, MD 🔍 Study Highlights: Examines waitlist and post-heart transplantation outcomes in children with Down Syndrome. Findings suggest outcomes comparable to pediatric heart transplant recipients overall. Challenges the notion of Down Syndrome as an absolute contraindication for heart transplantation. Key Message: Inclusive and equitable healthcare approaches can lead to positive outcomes in diverse patient populations. 📚 Earn 1.0 CME credit by engaging with this vital research. https://lnkd.in/d6vQKzPF #PediatricCardiology #DownSyndromeAwareness #HeartTransplant #MedicalEducation #cme

How can #Bayesian borrowing approaches enhance the statistical analysis of #baskettrials and #pediatric studies and what impact could these methods have on the evaluation of treatment efficacy in #rare indications? Emma Mackay from Inka Health, will be presenting at the Statistical Society of Canada / Société statistique du Canada Annual Meeting at Memorial University, Newfoundland and Labrador tomorrow afternoon in Room C2045. The session is organized by Aaron Springford from AstraZeneca and will be chaired by Audrey Béliveau from University of Waterloo. https://lnkd.in/gxw2iJEz In her talk, Emma will address the pressing challenges in evaluating efficacy for rare indications, focusing on the application of Bayesian hierarchical models, power priors, and meta-analytic predictive priors. These innovative approaches facilitate dynamic borrowing of information, improving statistical precision and power in #clinicaltrials where patient recruitment is a significant hurdle. Emma's discussion will include practical recommendations, such as leveraging historical control arms and integrating data from adult populations to support #pediatrictrials. Her insights into #baskettrials, which recruit patients based on shared #biomarkers across multiple disease types, highlight the potential for more efficient and effective #research. #BayesianMethods #ClinicalTrials #clinicaltrial #RareDiseases #BasketTrials #PediatricResearch #StatisticalInnovation #EfficacyEvaluation #DynamicBorrowing #DataScience #oncology #SSC2024 #HealthcareAnalytics #PrecisionMedicine #BayesianBorrowing #MedicalResearch #PatientCare #SSC #MemorialUniversity #pediatrics