Kudos’ Post

In #Sweden, they call it ”immunity debt” (”Immunskuld”) attributed to the ”lock downs” that never happened. 🙄 The obvious question how the novel virus SARS-CoV-2 has impacted our immunesystems is yet to be asked. No one dares to. ”COVID-19 causes long-term reduction of innate and adaptive immune cells which is associated with a Th2 serum cytokine profile. This may provide an immunological mechanism for long-term sequelae after COVID-19.” https://lnkd.in/dXdbgTPD

Receptors that activate the innate immune response, that recognize pathogens directly and those that signal for a cellular response. Proteins that recognize features common to many pathogens occur as secreted molecules and as receptors on cells of the innate immune system. Their general characteristics are contrasted with the antigen-specific receptors of adaptive immunity Unlike the receptors that mediate adaptive immunity, the receptors of the innate immune system are typically not clonally distributed. Visit our journal website for more updates: https://lnkd.in/dQ84mS8f (Source: Internet) Submissions are open for upcoming issue! Submit your manuscript to: immunologyallergy@maplesjournal.com #immunereceptors #immunology #antigens #innate #pathogens #immunesystem #adaptiveimmunity #allergicreactions #antibodies #proteins #molecules #characteristics #cellularresponse

The development of nasal polyps is associated with chronic rhinosinusitis, which is inflammation of the nasal passages and sinuses lasting 12 weeks or more. Research suggests those who get affected may have an abnormal immune response and different chemical markers in the mucus membrane (which lines the sinuses and nasal cavity), compared to those who do not develop nasal polyps. These chemical markers act like signs telling the body what it is and how to react.  Visit our journal website for more updates: https://lnkd.in/dQ84mS8f (Source: Internet) Submissions are open for an upcoming issue! Submit your manuscript to immunologyallergy@maplesjournal.com #inflammation #nasalpolyps #immunology #chemicalmarkers #chronicillness #mucusmembrane #allergicmembranes #sinus #nasalcavity #rhinosinusitis

Today, we join the International Union of Immunological Societies (IUIS) and the European Federation of Immunological Societies in celebrating the International #DayOfImmunology, an annual effort to promote the global benefits of immunology research! 🌎🔬🎉   This year’s event theme is “Immunity Through the Ages: Navigating the Science of Aging and Immunology.” Did you know that research led by BRI’s Bernard Khor, MD, PhD (pictured below), has found that the immune systems of people with Down syndrome look up to 17 years older than their actual age?   According to Dr. Khor, people with Down syndrome are more likely to experience unfavorable health outcomes related to the immune system, including a higher risk of contracting an infection, a lower level of response to vaccinations, and a higher risk of developing an autoimmune disease, like Hashimoto’s disease or celiac disease.   With the recent receipt of three new awards totaling over $7.5 million, scientists across labs at BRI are equipped to become a hub of knowledge about how the immune systems of people with Down syndrome can lead to a heightened likelihood for disease.   “The goal of our work is to improve the lives of people with Down syndrome, with the hope of also using our findings to learn more about the development of immune system diseases across other populations,” says Dr. Khor.   Learn more: bit.ly/4b8iBBU   #ImmunityAndAging #DownSyndrome #AutoimmuneDisease #Immunology

This new paper proposes an explanation for the higher prevalence of autoimmune diseases in females compared to males. The authors suggest that the ribonucleoprotein Xist, involved in X chromosome inactivation in females, trigger autoinflammatory responses absent in males. Using the pristane induced lupus in SJL/J mouse model, they found that inducing Xist expression worsened disease severity in male mice. Autoantibodies against Xist were also detected at higher levels in female human patients as in the lupus mouse model. However, despite the higher Xist levels following Dox induction of the Xist transgene in male mice, females still exhibited more severe disease. This suggests that Xist may not be the decisive driver of disease initiation but could facilitate progression together with other female related factors, since it is an immunogenic antigen that can be targeted by the immune system. #immunology #immunotherapy #antibodies #autoimmunedisease #lupus #immunesystem #immunity #vaccines #inflammation

The challenge of in vitro diagnostics (IVD) is to detect diseases and monitor health conditions. There are different technologies available to realize these assays, based on the same principle: they identify specific DNA/RNA segments or rely on specific antibody-antigen interactions to detect target components. It is then crucial to use suitable antibodies. At BioGenes, our high-quality monoclonal and polyclonal antibodies enhance the accuracy of PCR, ELISA, CLIA, and more, ensuring reliable disease markers detection and health monitoring. Partner with us to benefit from tailored immunization protocols, stringent quality control, and innovative solutions. Learn more here: https://lnkd.in/dMkwrUHr #InVitroDiagnostics #IVD #CustomAntibodies #HealthcareInnovation

Scientists have discovered novel immune responses that help explain how some individuals avoid getting COVID-19. Recently published in Nature, this study is part of the world’s first COVID-19 human challenge study. The team used a multi-allele panel of 44 SARS-CoV-2 antigen-specific #dCODE #Dextramer® reagents to study antigen-specific T cell dynamics by single-cell multi-omics. This study set out to capture immune responses right from exposure, in an immunologically naïve cohort for the first time. Individuals who immediately cleared the virus mounted subtle, never-seen-before immune responses including the activation of #MAIT cells and a decrease in inflammatory monocytes. High HLA-DQA2 expression before exposure was also associated with preventing sustained infection. Congratulations to all the researchers involved in this study for providing the most comprehensive timeline to date of the body’s immune response to SARS-CoV-2 exposure! Find the link to the full article in the comments!🙌 #immunology #singlecell #Tcells #immunologyResearch #immunity #immunemonitoring #antigensspecificity

📢 New Publication from our labs! We are excited to announce the publication of our latest research in the journal Case Reports in Infectious Diseases. Our study, titled “Evaluation of Neutralizing Capacity of Tixagevimab plus Cilgavimab (AZD7442) against Different SARS-CoV-2 Variants: A Case Report Study with Comparison to a Vaccinated Population,” provides valuable insights into the effectiveness of AZD7442 against various SARS-CoV-2 variants. 🔍 Key Findings: ➡️ AZD7442 demonstrated a higher initial neutralizing antibody (NAb) response compared to the primary COVID-19 vaccination, with a peak at 14 days post-administration. ➡️ The effectiveness of AZD7442 varied across different SARS-CoV-2 variants, with the highest neutralization capacity against the wild-type virus and reduced effectiveness against newer variants such as Omicron BA.5 and XBB.1.5. ➡️ The study suggests that while AZD7442 is effective for short-term prophylaxis, especially in frail patients, its administration schedule may need to be adjusted to ensure continued protection against emerging variants. ➡️ These findings emphasize the importance of continuous monitoring and potential adaptation of prophylactic strategies in the fight against COVID-19. Again an excellent collaboration between the Unité de Recherche en Pharmacologie Clinique et Toxicologie (URPC) - Namur Research Institute for Life Sciences (NARILIS) - Université de Namur, the Clinique Saint-Luc Bouge, the Clinique St-Pierre Ottignies and QUALIblood! 🔗 Read the full article here: https://lnkd.in/eYykHy8a #COVID19 #SARSCoV2 #AZD7442 #Evusheld #Research #Healthcare

The immune system’s job is to protect us from infectious intruders, but sometimes it gets confused and attacks the wrong cells, reacts to harmless substances, or fails to respond to intruders effectively. Learn what happens when the immune system goes awry in our new Biomedical Beat blog post. https://go.nih.gov/lbmPpJz #NIGMS #NIH #BiomedicalBeat #ScienceEducation #Biomedical #Biomed #Immunology #ImmuneSystem

Happy to share that our manuscript "Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques" has been published in the open-access journal iScience! Here we show that antibody signatures linked with protection against SARS-CoV-2 differ by anatomical compartment. Within the serum, neutralizing antibodies were the strongest correlate of protection and existed within a large network of antibody isotopes, subclasses, and functions. Within the lower respiratory tract and at the site of infection, however, non-neutralizing antibody functions were the strongest correlate of protection. These non-neutralizing functions were tightly linked with IgG and secretory IgA as well as FcγR-binding antibodies. Lastly, vaccine boosting at the mucosa elicited the strongest induction of these protective antibody signatures. Many thanks to co-first authors Dr. Xin Tong and Dr. Qixin Wang, and co-corresponding author Prof. Dan Barouch. #antibody #COVID19 #systemsimmunology https://lnkd.in/ehjPJEGV).