MDPI_Toxins’ Post

What do you think? 🤔 A recent study found that only 5% of #animalstudies lead to human treatments. Is this a wake-up call to improve study design or is it a success? The Center for Reproducible Science at the University of Zurich, an European Animal Research Association (EARA) member, published the results. Study author Benjamin Ineichen attributes the low success rate to many factors, saying "...you have to consider how difficult it is to develop effective new therapies and how great the utility of a drug is for people who suffer from an illness." Where do you stand on the topic? How do we improve the probability of success? Are there limitations in animal studies that are holding us back? Should we design animal experiments to more closely resemble the human trials that may one day follow? #RevolutionizingResearch #invivo

Dr. Juan Vargas, Maya Swenson, and Dr. Sara Place have a new publication in Translational Animal Science outlining methods for collecting an accurate methane phenotype of cattle in feedlot systems. Learn more about this publication and the findings in this video and blog: https://loom.ly/SCJsaAw

https://lnkd.in/gXV-ZEms Learn how researchers plan to study the connection between animal and human microbiomes.

All credit to Jarrod Bailey for an eloquent and thoughtful opinion piece on the role of the 3Rs! I would just like to point out one possible misconception: he quotes my paper (ref. 62) to back up a statement (on the subject of the need to focus on human rather than animal biology) that 'either the evidence is largely overlooked, or there is a belief that these issues can be overcome with better experimental technique and/or analysis (ref. 61–64) and/or genetic modification (ref. 16,65). This is in stark contrast to other scientific and engineering disciplines that try to rigorously challenge their models, and alter their approaches, based on solid data.' My paper describes the PREPARE guidelines (https://lnkd.in/d5YKB-5) which start with focus on what Jarrod wishes: better evaluation of the necessity, ethical acceptability, legality and translatability of the planned study. PREPARE highlights the need for a thorough literature search. PREPARE stands therefore in contrast to reporting guidelines, whose primary aim is to improve animal studies. My paper includes the statement: 'An assessment of the need to use animals at all must therefore be the first stage of the process when planning preclinical research or testing'.

https://lnkd.in/gXV-ZEms Learn how researchers plan to study the connection between animal and human microbiomes.

Establishment of a Testicular Ischemia Reperfusion (Testicular Torsion/Detorsion) Model in Rat for the First Research Project in the MAZE Animal Laboratory. Testicular torsion/detorsion Model in Rat, will serve as a valuable tool for investigating the pathophysiological mechanisms underlying testicular injury and potential therapeutic interventions. Mahdi Zhandi #MAZE #University_of_Tehran

A new study has shown that only 5% of new therapies passing animal trials were successfully approved for human consumption. The researchers looked at 367 therapeutic interventions and found that only 14 passed human clinical trials. Why? The scientists conclude that animal studies are often poorly designed, invalidating their results. They also point to "notable discrepancies in the contexts of animal testing versus human application" which can lead to less relevant results. Read the full study in PLOS Biology: https://lnkd.in/g5XWEGsM #HumanRelevant #BiomedicalResearch #AnimalTesting

We knew that there were problems in animal labs when our clients brought this issue up to us way back in 2017, but we didn't realize at the time that the NIH was also noticing the same problems. In 2022, ORIP (Office of Research Infrastructure Programs) organized a workshop titled "Enhance Rigor and Reproducibility in Animal Research by Managing Extrinsic Factors". Even we didn't know how on the mark SenSV was for managing this problem! Check out our blog post here all about this workshop https://lnkd.in/gGP35zQS

🌍🐾 On World Day for Laboratory Animals, we come together to raise awareness and advocate for the welfare of the animals that are used in scientific research. 🐁🔬 🔬 BMKGENE is proud to be a part of the scientific community dedicated to advancing knowledge and improving human and animal health. We recognize the importance of laboratory animals in our research endeavors and the ethical responsibility we bear towards them. 🌱🧪 💡 Through our cutting-edge technology and expertise in genomic sequencing, we decipher the genetic codes of laboratory animals, uncover valuable insights, and contribute to the advancement of personalized medicine. 🧬💊 #WorldDayForLaboratoryAnimals #AnimalWelfare #ScientificInnovation #CompassionAndRespect #Sequencing #Bioinformatics

The science of early development 🔬🍼 Behind every Earlyfeed solution lies decades of scientific research and a profound understanding of young animal biology. Our formulations are meticulously developed to support the digestive and immune systems from the earliest stages, ensuring optimal growth and health. 🐥🐮 Read all our latest articles at https://ow.ly/IcQq50QSXsn. #animalnutrition #earlyfeed