Listen to Liam Clifton and myself and learn about Quantum‘s approach to AI.
Join Liam Clifton and Roland Rosenau tomorrow at 2pm BST/ 3pm CEST/ 9am EDT to find out more about how Quantum customers such as Eikon Therapeutics and XENON Systems are using the Quantum end-to-end data platform to accelerate their workloads and improve productivity in HPC, research and scientific environments. https://lnkd.in/d7Cwcshp
Structural models can be error-prone. Fortunately, physics-based modeling plays a significant role for the refinement of these models and hence can improve the accuracy.
High-quality predicted protein structures have the potential to enable structure-based drug design across a broad array of drug discovery programs. However, the accuracy of predicted structures must be confirmed and refined before they can be confidently deployed in lieu of experimental structures. In a Commentary published today and featured on the cover of Cell, Schrödinger scientists describe how they use free energy perturbation (FEP) to validate and optimize protein structure models generated by methods such as AlphaFold, and leverage them to advance a variety of internal drug discovery projects. Read the full Commentary here: https://lnkd.in/esdUihYf
Empower your daily experiments with Polyplus Transfection Reagents! Choose among our 4 best-in-class transfection reagents to meet your specific needs depending on the Molecule Delivered, Targeted Cells and its Application. #Polyplus #Sartorius #TransfectionReagent
Senior Scientist at Merck| Innovator| Chromatography Workflow Builder| Passionate in Biotherapeutics Assay Development
Now on chemrxiv
Very pleased to share that the first two manuscripts describing some of our recent antibody-drug-conjugate (ADC) platform developments are now out on ChemRxiv (andsoon coming to a journal near you): 1) The invention of a tool molecule platform that allows conjugation reaction development without highly toxic compounds, including their use in custom-made microfluidic reactors and on larger, continuous scale https://lnkd.in/eaeCrDv7 2)The catalytic, electrochemical reduction of disulfide bonds under conditions compatible with biomolecules… peptides, proteins,and antibodies. https://lnkd.in/e4U5pG-F Thanks to the team for their amazing work. Serge Ruccolo Cecilia Bottecchia
Spectral flow cytometry continues to push the boundaries of multiparameter cell analysis, enabling researchers to delve deeper into cellular subsets and integrate results with high-performance cell sorting. Join our webinar on August 29th, as Dr. Andrew Draghi, II Ph.D., MS from Sony Biotechnology Inc. demonstrates the power of the FP7000 Spectral Cell Sorter. He’ll guide you through the design and analysis of 20+ color panels using the ID7000™ Spectral Cell Analyzer and show how to efficiently transition these panels to the FP7000 without the need for panel optimization or redesign - saving both time and reagents. Don’t miss this opportunity to learn how to design high-parameter spectral panels - register to attend the live event or catch the recording afterwards: https://lnkd.in/di-92wuQ #flowcytometry #spectral #spectralflowcytometry #cellanalysis #cellsorting
Development of an in vitro Blood Brain Barrier (BBB) model was always going to be challenging due to multiple factors including difficulty in replicating its architecture and cellular interactions, seeking consistency in mimicking their functional properties effectively and standardisation. It is therefore not surprising that there are not many suitable commercially available models available on the market. At Cellomatics Biosciences Ltd, we pride ourselves in constantly challenging ourselves and in offering innovative solutions. We have now successfully developed an in vitro Blood Brain Barrier model using a tri co-culture system. This model provides a controlled environment for studying drug permeability, cell-to-cell interactions, and transporter activity, offering a promising solution for preclinical research. #preclinical #CRO #biology #BBB
Over the years, several companies have designed different models to represent the blood-brain barrier (BBB) in vitro. These range from simple one cell type models to complex organ on a chip or microfluidic structures. However, there are several drawbacks associated with these models, with single cell models not receiving feedback from the other cells surrounding the vasculature and more complex models being limited by their expense and low throughput. INNOBEX™ was created in house by the Cellomatics team as a solution to these issues, with three primary cell types making up the model. Read our latest blog to learn more//bit.ly/4d9MnXq #BBB #BloodBrainBarrier #CRO #LifeSciences
Kicked off with discussions at the workshop day with topics including: 💡 Workshop A - Unveiling the Protein Universe: Structure-Based Drug Design with NMR, X-Ray Crystallography, & Cryo-EM 💡 Workshop B - Navigating Protein Samples for Each Structural Technique to Optimize Protein Production & Supercharge Structure Determination 💡 Workshop C - Diving Deep into Data: Cultivating Data Acquisition & Management for Structural-Based Drug Design #SBDDSummit #structurebaseddrugdesign #drugdesign #cryoem #xraycrystallography #nmr #structuralbiology
And we are off!!! Busy morning here in Boston at the pre-conference workshop day for the Structure-Based Drug Design Summit. I'd like to thank all of our partners, Thermo Fisher Scientific, CryoCloud, Curia, Immuto Scientific, PROTEROS biostructures GmbH, PUXANO, Helix Biostructures, NanoImaging Services, and Biortus for making this possible. Stay tuned for more updates this week!!! #structurebaseddrugdesign #structuralbiology #cryoEM #cryoTEM #NMR #XRaycrystallography #SBDD
Enterprise collaboration is quite important in accelerating drug development. check out this one !!!
Schrödinger is excited to be attending Festival of Biologics USA, April 15-17 in San Diego. Stop by our booth #213 to learn about Schrödinger's computational solutions for antibody design, peptide discovery, and enzyme engineering. Don't miss the presentation by Schrödinger's Eliud Oloo entitled "Candidate optimization using rigorous structure-based computational modeling and collaborative enterprise informatics." Learn more: https://hubs.li/Q02sJRnG0
🔬 What unique insights can cryo-TEM per-particle imaging reveal about LNPs? 🔎 In a joint study by Phosphorex and NIS, we used #cryoTEM imaging to examine the effects of process changes on #LNP #morphology, particularly #bleb features, which cannot be easily observed with other analytical methods. 📑 To read the results, download the whitepaper now: https://lnkd.in/gia_uTZc
Explore our Drug Discovery Platform focusing on Cellular Differentiation at https://hubs.la/Q02HMrQG0
🔬 What unique insights can cryo-TEM per-particle imaging reveal about LNPs? 🔎 In a joint study by Phosphorex and NIS, we used #cryoTEM imaging to examine the effects of process changes on #LNP #morphology, particularly #bleb features, which cannot be easily observed with other analytical methods. 📑 To read the results, download the whitepaper now: https://lnkd.in/ghd_Ujgz