Thank you to everyone who came to our booth at #CYTO2024 in Edinburgh and joined the Sony Biotechnology commercial tutorials. We appreciate you! For more information on our new FP7000 system, be sure to join our mailing list here ➣ https://ow.ly/qVfX50RC2nE Until we see you in Denver, it's a wrap! #SonySpectral
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I am proud to share our work in #JMedChem for one-pot #PROTAC synthesis via photochemical C(sp2)-C(sp3) cross coupling and amide bond formation. In the paper you can find comprehensive scopes detailing the substrate tolerance of the photochemical C(sp2)-C(sp3) coupling on various CRBN binders and linker motifs. The one-pot synthesis grants rapid access to BRD4 PROTACs in a single step via heterobifunctinal linker building blocks. This might be useful to #MedChemists looking to overcome the synthetic hurdles of making a lot of #PROTACs fast for #drug discovery programs. You can read about our work in #JMedChem here: https://lnkd.in/eyCiE3HG and can find some nice illustrations of our #PROTAC factory on the cover of J. Med. Chem. as well. This project was a great collaborative effort between Boehringer Ingelheim and the University of Mainz. Many thanks to Christine Marie Arndt, Jacqueline Bitai, Jessica Brunner, Till Opatz, Paola Martinelli, Andreas Gollner and Kevin Sokol. Special thanks to Harald Weinstabl for funding these wild ideas that eventually turn into something useful for the daily work in drug discovery.
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Iris Kinetics technology empowers scientists to explore complex binding interactions with precision, speed, and label-free convenience. Leveraging the power of #microarrays, in a single experiment (lasting less than an hour), researchers can characterize the binding affinities of small or large biomolecules to multiple probes. The technology is transparent to DMSO, resulting in clean binding data for small molecule drug candidates investigations. This approach is most powerful when a profile of binding affinities is needed. Visit us in Philly at #BPS2024 #axiVEND booth 709, you’re in for an exciting glimpse into the future for diagnostic applications! #m2automation #drugdiscovery
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Our patented assay ArrayPlex™ is uniquely able to generate hits by screening two libraries against each other without prior knowledge of ligand or target. #microarray #highthroughput #drugdiscovery https://lnkd.in/eadZi_NY
Inkjet Microarray Technology » ArrayPlex™ Spot-on-Spot Microarrays
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We are counting down our top 3 biologics blog posts of 2023! #1 explores the novel use of mechanistic modeling in combination with Computational Fluid Dynamics (CFD). 👉 https://ow.ly/fM3n50QlmUs
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Effortlessly Add Multiple Fragments for Co-crystallization Experiments using the Rock Maker Read this application note to learn how the Rock Maker software allows for easy creation of co-crystallization experiments using fragments and ligands. This feature is particularly useful for researchers performing structure-based drug discovery using small-molecule fragments. Learn more: https://hubs.ly/Q02xnP-y0 #Crystals #Crystallization #Crystallography #RockMaker #Formulatrix
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Reaxys supports successful early drug discovery by providing chemists with the shortest path to relevant literature, patent information, bioactivity, compound properties, and experimental procedures. Follow our new 7-step series to see how Reaxys helps you step by step to understand the chemical space for your target, obtain SAR data for your compounds, avoid competitive blindspots, avoid structural motifs with known safety issues and accelerates synthesis of novel compounds. At each step of the Design-Make-Test-Analyze cycle, Reaxys is with you. Follow this series of posts for more detail on each step. The first step will be posted on February 26th. #DMTAcycle #Reaxys #Research #Elsevier
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🌟 We are thrilled to announce that our company is a proud sponsor of the 12th Peptoid Summit 🌟 💡 Peptoids have been making significant strides as potential therapeutics and self-assembling polymers for material development. With their unique structural properties and versatility of side chains, peptoids offer incredible potential in drug discovery and material sciences. 👨🔬 At Gyros Protein Technologies, we understand the importance of supporting scientific advancements, which is why we are committed to providing cutting-edge instrumentation that addresses the synthetic challenges posed by peptoids. ⭐ Our flexible software, induction heating technology, improved chemical compatibility, and inert experimental conditions enable the synthesis of challenging peptoids, leading to higher purity and efficiency. 👉 We proudly showcase how our instrumentation facilitates the parallel synthesis of high-purity peptoids and peptoid analogs, including the self-assembling diblock peptoid and the opioid receptor agonist peptoid-peptide hybrid. 🙌 We are eagerly looking forward to connecting with fellow innovators and researchers at the Peptoid Summit. #purepep #peptoid #synthesis
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Did you miss any of our February news and highlights? Here is a comprehensive summary of our posts for this month: News & Conferences 1. Meet Olga Tarkhanova and Rita Gaidar at the 9th Fragment-based Drug Discovery Conference in Cambridge! 2. Also, Chemspace team will be happy to catch up at the Conformational Design in Drug Discovery in Stevenage. 3. Check out our Website Update - Discovery CRO page! #Meet_Chemspace_team: Meet Chemspace Team – Mariana Perebyinis, Data Scientist We continue our series of posts “Building Blocks for DEL”: Part 3. Bis(catecholato)silicates. New Library Sets & Updates: Our General Pre-Plated Library has expanded - now over 672,000 compounds are available for off-the-shelf ordering! Meet a new post in the “Chemspace products – Biologics for Research” series: Estrogen receptors (ERs). Building Block and Screening Compound Sets: Explore Analogs to New Biological Tool Compounds (Camizestrant). Weekend article and corresponding service: Shape-Aware Synthon Search for virtual screening of synthon-based chemical spaces. There is a NEW SUPPLIER this month: RR Scientific LLC. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures
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Ever wonder how Nuvolos performs on a complex biotech pipeline? Using Cellranger Multi, we show you how easy, flexible, and performant it is. https://lnkd.in/eDru3ah2
Nuvolos - How to run a Cellranger pipeline on Nuvolos
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We continue to summarize the latest updates from Chemspace! Check out our January post roundup: https://lnkd.in/eYKJV434 News & Collaborations: 1. Meet new Chemspace COO – Olena Strapak (née Tkachuk)! 2. NexMR AG and Chemspace announced the collaboration 3. Our New Biologics Supplier - Reed Biotech LTD! #Meet_Chemspace_team: 1. Meet our Data Scientist - Serhii Hlotov Explore New Series “Building Blocks for DEL”: 1. Part 1. Redox-Active Esters 2. Part 2. Hantzsch Esters Building Block and Screening Compound Sets: 1. “Molecule Builder”- check out a new post about Iptacopan 2. Discover Analogs to New Biological Tool Compounds - LY3522348 #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures
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Life Sciences/Med Tech CFO, ex Thermo Fisher, ex BD, ex Cisco | Top Bay Area Biotech CFO nominated l Who’s Who in Finance nominated
5moProud of the strong support to Sony Biiotechnology solutions from the Flow community!