DNAstack

🗣️ Such an absolute pleasure to present today at the Global Alliance for Genomics and Health 12th Plenary in Melbourne, Australia alongside Ma'n H. Zawati (irl) and Marc Fiume (online)! 🌏 We're in the process of devising an ethico-legal guidance document on the use of #generativeAI in genomics research — highlighting the need for: • technical robustness through auditing ⛓️ • privacy protection 🔐 • lowering the risk of biased outputs ⚖️ • explainability 📣 and other key considerations when developing and using this tech 🤖 This is such a great community of people doing important and incredible research and work. Grateful to be here and to be exploring Melbourne for the first (but hopefully not the last) time too 🗺️

Parkinson's is a neurodegenerative disorder that causes problems with movement, mental health, sleep, pain and other health issues. More than 10 million people are living with Parkinson's, and prevalence is increasing. Multi-modal analysis of genomic and other data represents a significant opportunity to better understand the disease and discover how to slow or stop its progression. This case study describes groundbreaking work in partnership with Aligning Science Across Parkinson’s | ASAP to build the ASAP Collaborative Research Network Cloud. It has been an honour to work with ASAP, The Michael J. Fox Foundation for Parkinson's Research, DataTecnica LLC, and Verily to take technology to the fight against Parkinson’s Disease. 📖 Case Study: https://lnkd.in/gZQjvvuV ☁️ ASAP CRN Cloud: https://lnkd.in/g8ESckKy Thanks to our partners and data donors for your commitment to #parkinsonsresearch, #openscience, and #precisionhealth.

We are excited to launch the ASAP CRN Cloud, a data-sharing tool designed to advance #ParkinsonsDisease research by allowing researchers to share, access, and work directly with other experts to distill discoveries. We developed this tool in collaboration with our implementation partner, The Michael J. Fox Foundation for Parkinson's Research and our technical partners at Verily, DNAstack, and DataTecnica LLC. Currently featuring a unique set of sequencing data from over 150 donors, the CRN Cloud dataset offers the potential for unprecedented insights into #neurodegeneration. The database will continue to expand, with 629 donors contributing to the final harmonized dataset. Read our blog to learn more about the CRN Cloud: https://bit.ly/3VUMlO0

#SickKids Senior Scientist, Dr. Adam Shlien secures $6 million in funding through @Genome Canada’s Genomic Applications Partnership Program (GAPP) to advance his ground-breaking cancer diagnostic platform toward clinical implementation.  Shlien, who holds a Garron Family Chair in Childhood Cancer Research, and his team developed the novel machine-learning algorithm at SickKids to rapidly classify more than 90 per cent of paediatric sarcomas – a cancer that can occur anywhere in the body and is one of the most difficult to diagnose. Though rare in adults, sarcomas make up approximately 20 per cent of solid cancers in children. With this funding, the tool will move into clinical labs and expand beyond paediatric care. “Our technology is the first comprehensive approach for the diagnosis of sarcoma patients of any age,” Shlien says. In Canada, SickKids and Mount Sinai are the two hospitals where patients with sarcomas are most referred to for care, making Shlien’s tool an asset for diagnosis. #SickKidsInnovation The Hospital for Sick Children Adam Shlien Ihor Boszko Konrad Powell-Jones Oksana Goncharenko Sedric Pankras, PhD, MBA Stephanie Tammam Jevin Francis Kamran Rezai Maureen Onuchuku, PMI-ACP®, CSM®, CSPO® Anita A. Cloutier Read more ➡️ https://lnkd.in/ghcj3cZg

Autism Speaks’ MSSNG database, the world’s largest autism whole-genome dataset, recently expanded to include an additional 2,489 fully sequenced genomes in the project’s cloud-based dataset. Genomic data is now available for 13,801 individuals, including over 6,000 autistic people and over 7,000 of their family members. https://okt.to/EKk0gJ

Today, we’re taking an important step to accelerate the impact of AI in genomics and health research. We’ve partnered with Vector Institute, a global leader in AI, to leverage their expertise as we bring new AI experiences to the market. The collaboration will fuse together the latest techniques in AI/ML with our platform for standards-compliant and privacy-preserving federated insights, to deliver a new way of making discoveries across sensitive datasets that is faster and safer than ever before. We are grateful to Vector and our many partners who share in this vision. 🧠 - Vector Institute (https://lnkd.in/gQfFJZt8) 🧬 - Omics AI, DNAstack's software platform (https://omics.ai) 📰 - Announcement (https://lnkd.in/gHbKjv2x) #ai #openscience #thefutureisfederated #genomics #precisionhealth

We are pleased to announce a groundbreaking new initiative – In collaboration with DNAstack and Verily, Target ALS has launched a first-of-its-kind data portal that will provide no-strings-attached access to comprehensive datasets and analysis tools to fuel the discovery of treatments and biomarkers for ALS. Through the portal, researchers worldwide can access well-characterized data collections from Target ALS’ Scientific Core Facilities, including postmortem tissue, longitudinal biofluids, and stem cells. Read the full announcement: https://bit.ly/4cBuO3B Take a look at the platform at dataportal.targetals.org #ALSResearch #EveryoneLives #Biomarkers #ALS #EndALS

Today, we’re excited to announce a new ISO standard, Requirements for interoperable systems for genomic surveillance. Genomic surveillance combined with rapid realtime data sharing is the most important tool we have for detecting and stopping the spread of infectious diseases, like COVID. Throughout the COVID pandemic, we had the privilege of working together with our provincial and federal government to implement a solution for tracking and sharing information on variants of concern. It became clear that the centralized model of data sharing is fraught with issues — it makes data linkage difficult and causes significant time delays, misaligned incentives, and data hoarding. Centralization just doesn’t work at national or planet scale. This document describes design principles and the service and standards requirements to enable an interoperable system for federated genomic surveillance. It represents a vision, shared by our partners, for the future of pandemic prevention. We are extremely grateful to have worked with the Canadian and international community in the preparation of this standard, including: Don Newsham, Grant Gillis, Bron Kisler, Evgueni Loukipoudis, Helen Lang, Christine Beyaert, Lindsay Smith, Ashley Hobb, Miro Cupak, Heather Ward, Jeremy Adams, members of the Global Alliance for Genomics and Health, and many others, with support from Digital, Innovation, Science and Economic Development Canada, and Genome Canada. Read: https://lnkd.in/gNZPDmXD

🧠 GA4GH and the International Neuroinformatics Coordinating Facility (INCF)-org welcome interested organisations worldwide to join a new Neuroscience Community. https://bit.ly/3N6HxQT These two leading standards bodies aim to help power a global data network that will speed up answers in autism, Parkinson’s, addiction, and more. In the GA4GH & INCF Neuroscience Community, international partners meet to lay the groundwork for connecting neuroscience and genomic data. The group will develop the standards, collaborations, and systems needed to enable data visiting across a global network. The GA4GH & INCF Neuroscience Community aims to expand neuroscience and genomic data networking around the world — ramping up what many members are already doing. In Ontario, Canada, for example, Ontario Brain Institute have a Brain-CODE platform with neurological data from more than 20,000 people. And DNAstack developed a Neuroscience AI network that researcher Azadeh Kushki of Holland Bloorview Kids Rehabilitation Hospital used to make an important discovery: neurodivergent kids might be prescribed medication differently based on their ethnicity and family income. The GA4GH & INCF Neuroscience Community will help get answers faster for patients and people everywhere while respecting the human rights of people who donate their data. Learn more and join today: https://bit.ly/3N6HxQT