ACTIV-H

2025: A Year of Growth 🚀 We’ve already dove into 2025, building on the momentum of an incredible 2024 - a year of meaningful connections, key improvements, and ambitious planning. Thanks to the trust of our clients and partners, we’re stepping into this new year stronger and more determined than ever. At ACTIV-H, we contribute to drug discovery by exploring novel chemical spaces, enabling the design of molecules beyond the reach of conventional chemistry. With a differenciating technology and set of expertise, we support pharmaceutical research with innovative solutions to help explore new chemical spaces. Our focus for 2025 is clear: growth, innovation, collaboration, and trusted partnerships. We’re expanding our reach, advancing new projects, and staying present where it matters most. You’ll find us at these key events: 📍 Bio-Spring Europe (March - Milan) 📍 Swiss Biotech Day (Mai - Basle) 📍 BIO International Convention (June - Boston) 📍 EFMS-ASMC (September - Porto) 📍… These gatherings are the perfect opportunity to meet, exchange ideas, and explore new collaborations. If you’ll be attending, let’s connect! Here’s to making 2025 a year of impact and opportunity. Let’s keep the momentum going! #2025 #Growth #Innovation #Collaboration #TrustedPartnerships #SmallMolecules

🔬 Advancing Controlled Methylation in Drug Discovery The controlled incorporation of methyl groups into drug candidates represents a transformative step in medicinal chemistry, offering unique advantages to overcome key challenges in the drug discovery process. Despite its potential, accessing selective methylation methodologies remains a considerable hurdle.   The impact of methylation in medicinal chemistry Methylation brings multiple benefits to drug design, such as ✅ Increased potency ✅ Enhanced metabolic stability ✅ Improved binding affinity ✅ Optimized pharmacokinetics ✅ The renowned ‘magic methyl’ effect - enhancing activity by even slight structural modifications.   We’re glad to share a recent highlight in OrganicProcessResearch& Development OPRD) showcasing the outstanding work led by our CSO & co-founder Prof. Sébastien Thibaudeau and his team, as published in Nature Communications: “Leveraging Long-Lived Arenium Ions in Superacid for Meta-Selective Methylation”. This innovative method introduces a novel approach to meta-selective methylation of aromatic compounds, unlocking the ability to generate long-lived arenium ions that facilitate precise functionalization at the meta position. Key Advantages of the Method ✅High selectivity and yields ✅Broad substrate scope ✅Applicability across a diverse range of functionalized (hetero)aromatics—from standard building blocks to active pharmaceutical ingredients (APIs). This technique offers substantial benefits over existing methylation methods, accessing highly desirable 1,3-disubtituted arenes, providing medicinal chemists with new tools for selective late-stage functionalization.   Read more in the OPRD highlight: https://lnkd.in/ecp5_dWP Explore the full publication: https://lnkd.in/e-SbbnNB ACTIV-H: Expanding the Boundaries with Superaicid Flow Chemistry ACTIV-H builds on this technology, bringing it further with our Superacid Flow Chemistry offering tailored solutions through similar transformations and beyond. Our innovative platform brings several critical advantages : ☑ Optimization of pharmacological profiles ☑ Modulation of biological activity ☑ Exploration of new chemical space - enabling the creation of analogs with improved properties. As your R&D partner, we are uniquely positioned to support your drug discovery programs. Let’s discuss how our specialized technology can accelerate your research and help solve your current challenges in medicinal chemistry. Connect with us to explore the potential of our platform : contact@activ-h.com. #MedicinalChemistry #DrugDiscovery #ControlledMethylation #CRO #FlowChemistry #LateStageFunctionalization

🔬 Advancing Controlled Methylation in Drug Discovery The controlled incorporation of methyl groups into drug candidates represents a transformative step in medicinal chemistry, offering unique advantages to overcome key challenges in the drug discovery process. Despite its potential, accessing selective methylation methodologies remains a considerable hurdle.   The impact of methylation in medicinal chemistry Methylation brings multiple benefits to drug design, such as ✅ Increased potency ✅ Enhanced metabolic stability ✅ Improved binding affinity ✅ Optimized pharmacokinetics ✅ The renowned ‘magic methyl’ effect - enhancing activity by even slight structural modifications.   We’re glad to share a recent highlight in OrganicProcessResearch& Development OPRD) showcasing the outstanding work led by our CSO & co-founder Prof. Sébastien Thibaudeau and his team, as published in Nature Communications: “Leveraging Long-Lived Arenium Ions in Superacid for Meta-Selective Methylation”. This innovative method introduces a novel approach to meta-selective methylation of aromatic compounds, unlocking the ability to generate long-lived arenium ions that facilitate precise functionalization at the meta position. Key Advantages of the Method ✅High selectivity and yields ✅Broad substrate scope ✅Applicability across a diverse range of functionalized (hetero)aromatics—from standard building blocks to active pharmaceutical ingredients (APIs). This technique offers substantial benefits over existing methylation methods, accessing highly desirable 1,3-disubtituted arenes, providing medicinal chemists with new tools for selective late-stage functionalization.   Read more in the OPRD highlight: https://lnkd.in/ecp5_dWP Explore the full publication: https://lnkd.in/e-SbbnNB ACTIV-H: Expanding the Boundaries with Superaicid Flow Chemistry ACTIV-H builds on this technology, bringing it further with our Superacid Flow Chemistry offering tailored solutions through similar transformations and beyond. Our innovative platform brings several critical advantages : ☑ Optimization of pharmacological profiles ☑ Modulation of biological activity ☑ Exploration of new chemical space - enabling the creation of analogs with improved properties. As your R&D partner, we are uniquely positioned to support your drug discovery programs. Let’s discuss how our specialized technology can accelerate your research and help solve your current challenges in medicinal chemistry. Connect with us to explore the potential of our platform : contact@activ-h.com. #MedicinalChemistry #DrugDiscovery #ControlledMethylation #CRO #FlowChemistry #LateStageFunctionalization

What an amazing few days it was at CPHI Milan 2024! From October 8-10, ACTIV-H attended this premier event, where we engaged in insightful discussions with key players in the industry. The conversations we initiated were invaluable, opening new avenues for collaboration and innovation in small molecule synthesis and drug discovery. A huge thank you to everyone who took the time to connect with us! We are excited about the future and eager to build on these discussions. Let’s keep the momentum going! 🚀 #CPHIMILAN2024 #DrugDiscovery #Innovation #Synthesis #FlowChemistry #Smallmolecules

It's the day @CPHI Milan ! Great innovations and technologies for the future of pharma. Let's connect to talk about how our technologie Can help reach a New chemical diversity with ACTIV-H. Feel free to get in touch here : contact@activ-h.com #pharma #innovation #smallmolecules #APIs

ACTIV-H rejoint la dynamique communauté de France Chimie Nouvelle-Aquitaine ! 🎉   Nous sommes ravis et honorés de faire désormais partie de la communauté qui façonne l’avenir de l’industrie chimique en région. Un immense merci à France Chimie Nouvelle-Aquitaine pour l’accueil chaleureux et le superbe post de bienvenue. 🙏   Chez ACTIV-H, nous sommes impatients de collaborer avec les acteurs clés de la chimie régionale, de partager nos expertises et d’apporter notre contribution aux nombreuses initiatives. Ensemble, nous relèverons les défis de demain et ouvrirons de nouvelles perspectives pour notre secteur en Région Nouvelle-Aquitaine ! 💡   A très bientôt aux prochains événements et projets !   Notre activité ⚗ Chez ACTIV-H, nous sommes spécialisés dans la synthèse de nouvelles molécules et dans l'enrichissement de la diversité chimique pour nos clients. Nos services et technologies de pointe, basés sur la chimie des (super)acides et les technologies de flux avancées, ouvrent la voie à une diversité moléculaire sans précédent. Une stratégie qui ouvre des perspectives concrètes pour le secteur de la découverte de médicaments en explorant des espaces chimiques nouveaux. En réalisant des transformations directes et sélectives souvent inaccessibles par les méthodes traditionnelles, nous offrons une alternative nouvelle pour relever les défis liés au développement de nouveaux traitements. Offrir de nouvelles alternatives au service de la santé est essentiel, et notre offre de diversification chimique représente une nouvelle option sur le marché.   Les avantages de nos solutions 🚀 ▶ Accès à des molécules uniques avec une boîte à outils complémentaire ▶ Accès à de nouveaux espaces chimiques et de propriété intellectuelle ▶ Un mode d'activation moléculaire unique ciblant des positions inertes ou métaboliquement sensibles ▶ Revitalisation des molécules existantes en libérant de nouvelles possibilités dans la découverte de médicaments ▶ Un large portefeuille de transformations   Collaborons 🤝 ! N'hésitez pas à nous contacter ici 📧 contact@activ-h.com pour en savoir plus sur notre technologie ! 🌐 www.activ-h.com #FranceChimie #NouvelleAquitaine #Chimie #Innovation #Collaboration #Industrie #Réseau  

Join us at #CPHIMilan 2024 ! 📅 8th - 10th October 📍 Fiera Milano – Italy ! At ACTIV-H, we specialize in delivering novel molecules and enhancing the chemical diversity for our clients. Our cutting-edge services and technology, rooted in (super)acid chemistry and advanced flow technology, pave the way for unparalleled molecular diversity. This innovative approach enables direct and selective transformations that are unattainable through traditional methods. "Offering new alternatives in the service of health is essential" says Prof. Sébastien Thibaudeau, co-founder and CSO of ACTIV-H. ''Our chemical diversification offer is a new option, and our R&D program opens up concrete perspectives in this field. How We Can Support you ▶ Access to unique molecules with an alternative and powerful toolbox ▶ Explore new chemical and IP spaces ▶ A unique mode of molecular activation targeting Inert or Metabolically Sensitive Positions ▶ Revitalizing Existing Molecules by unlocking new possibilities in drug discovery Let's Collaborate Reach out today to explore possible synergies as a trusted R&D partner in Your Drug Discovery Endeavours. Request a meeting with our expert here : zahra.abada@activ-h.com. or on the CPHi event planner. #Innovation #Ingredients #drugdiscovery #APIs #Intermediates #Buildingblocks #Research #CPHIMilan

Join ACTIV-H at CPHI Milan 2024! We’re pleased to be present at the next CPHI Milan event from October 8-10, 2024! Meet Dr Zahra ABADA, our CEO, to discover how ACTIV-H unique technology and expertise can help accelerate your pipeline and propel your early drug discovery projects forward. 📅 Schedule a short meeting here : zahra.abada@activ-h.com At ACTIV-H, we specialize in delivering novel molecules and enhancing the chemical diversity for our clients. Our cutting-edge services and technology, rooted in (super)acid chemistry and advanced flow technology, pave the way for unparalleled molecular diversity. This innovative approach enables direct and selective transformations that are unattainable through traditional methods. "Offering new alternatives in the service of health is essential" says Prof. Sébastien Thibaudeau, co-founder and CSO of ACTIV-H. ''Our chemical diversification offer is a new option, and our R&D program opens up concrete perspectives in this field." What We Offer •Access to unique molecules with a complemetary and powerful toolbox •Explore new chemical and IP spaces •A unique mode of molecular activation targeting Inert or metabolically sensitive positions •Revitalizing Existing molecules by unlock new possibilities in drug discovery We look forward to meeting you in this exciting italian edition 'at the heart of Pharma’ and explore how our unique platform can benefit your projects. See you there! #CPHIMilan #PharmaEvent #Research #deeptech #Networking #Innovation #PharmaIndustry #SmallMolecules

🔔 It’s Day 2 of #EFMCISMC2024 in Rome! We are glad to be here, soaking in all the insights and innovations in medicinal chemistry. If you’re at the symposium and want to chat about the latest trends in drug discovery or explore how we can access unique small molecule, feel free to reach out here : contact@activ-h.com - let’s make the most of this amazing event together! #MedicinalChemistry #DrugDiscovery #smallmolecules #innovation