Olink Proteomics

Join us at the Olink Proteomics World Virtual Conference! This event features the latest advancements in proteomics and proteogenomics. Connect with peers, identify potential collaborations and learn about how advanced protein biomarkers’ discovery tools can easily be applied into your own research. See agenda with 3 tracks: https://bit.ly/3Wiz9Cz Drug Discovery Identification of protein biomarkers for new robust drug targets. Learn about available cohorts and sample collections. Biomarker Discovery / Clinical Translation Identify actionable protein biomarkers to reduce the gap between genotype and phenotype. Multiomics and Proteogenomics Disease risk prediction with polygenic and proteins risk scoring in the ageing population.

Multiple myeloma (MM) is an incurable plasma cell malignancy for which the mechanisms underlying its significant heritability remain unclear. Our #weeklyread describes an extensive multiomic meta-analysis study from Lund University that identified key mechanisms involved in MM risk. Olink® Explore 3072 data from the UK Biobank Pharma Proteomics Project (UKB-PPP) was analyzed together with extensive GWAS, transcriptomic, epigenomic and cell-based data to characterize the genetics and causative factors associated with MM. Key highlights • Identification of 3 different target genes with known roles in telomere maintenance enabled MM risk causality to be established for telomere length. • The UKB-PPP dataset identified 9 MM risk loci with trans-pQTLs (gene variants linked to protein expression levels) for 21 different proteins. • Mendelian Randomization (MR) indicated likely causal associations to MM for BCMA and IL5RA – the levels of one or both of these proteins were associated with all 9 risk loci. • Completely distinct genetic risk variants implied that longer telomeres and BCMA/IL5RA-dependent amplified B-cell responses represent independent risk mechanisms for MM. The authors concluded, “Our results represent an analysis of genetic MM predisposition, highlighting causal mechanisms contributing to MM development”. Read the article: https://lnkd.in/dKTCYwUb

Welcome to the Olink Certified Service Provider Network, Sirona Dx! Sirona Dx is a leading technical CRO specializing in single-cell, multi-omics and spatial biology services. Their highly experienced team excels in the design, optimization and bioinformatics analysis of complex multi-analyte assays. Operating within GCLP and CLIA-accredited laboratories, they help advance biomarker discovery and accelerate therapy development for clients across the globe. Ready to start your multiomics project? Connect with Sirona Dx today: https://bit.ly/4emDuev #Olink #SironaDx #Proteomics #Multiomics #DrugDevelopment #ClinicalResearch #OlinkCertifiedServiceProviders

What proteomics applications are you most excited about? At the Olink Proteomics World Virtual Conference, Professor Frank Schmidt from Weill Cornell Medicine will discuss how proteomics can enhance our understanding of infectious disease mechanisms, and Professor Amy Fu from The Hong Kong University of Science and Technology will explore how proteomics is revolutionizing the diagnosis and monitoring of Alzheimer’s Disease. Register today to learn more from over ten distinguished speakers' presentations: https://bit.ly/3MsUZ0v You’ll get access to the recordings afterwards. #OlinkProteomicsWorld

Exciting News - we’re thrilled to welcome The Immune Monitoring and Cancer Omics Laboratories (IMCO) to the Olink® Certified Service Provider Network for Olink® Target, Focus, and Flex! IMCO, part of the CLIA-certified Knight Diagnostic Labs at the OHSU Knight Cancer Institute, is a boutique CRO specializing in cutting-edge assays and analytics for translational research. They have built a GLP-like infrastructure of cutting-edge technologies powered by robust actionable analytics, specializing in deep integration of basic science with clinical research, with the overarching purpose focused on advancing the standard of care for all patients and developing new therapeutics to fight disease. Want to be part of the Olink CSP network? Apply today: https://bit.ly/4dIO8fw #Olink #IMCO #Proteomics #Multiomics #CancerResearch #PrecisionMedicine #ClinicalResearch #Oncology #OlinkCertifiedServiceProviders

We’re excited to share that we currently have special offers for Olink Signature Q100 + Target bundles to help you integrate an end-to-end biomarker research solution into your lab. Sign up today to discuss the most suitable offer with our team: https://bit.ly/3AKEcn9

Join Us at the Olink Proteomics World Digital Conference! On September 26, let’s discover the latest breakthroughs in proteomics and proteogenomics, presented by leading scientists in immunology, oncology, neuroscience, ageing, inflammation, and more. This virtual live event is a unique opportunity to connect with peers, explore potential collaborations, and learn how advanced protein biomarker discovery tools can be seamlessly integrated into your research. Explore the complete speaker list on three tracks: • Drug Discovery • Biomarker Discovery / Clinical Translation • Multiomics and Proteogenomics Register today to secure your participation online and access the event recording afterwards! https://bit.ly/3YZCCaY #Olink #Proteomics #OlinkProteomicsWorld #Multiomics #Biomarkers

This #weeklyread reports on a remarkable study led by researchers from Oxford University, who developed an accurate, protein-based aging clock using data generated with the Olink® Explore 3072 high-throughput proteomics platform. After measuring ~3,000 proteins in over 51,000 individuals of UK European, Finnish, and Chinese genetic backgrounds from 3 independent cohorts, machine learning was applied to derive a 204-protein “ProtAge” model that could predict chronological age with almost 95% accuracy. Key highlights: Further biostatistical analysis reduced the initial model to a more practicable aging clock comprising of just 20 proteins (“ProtAge20”) that retained ~95% of the original prediction performance. Cell adhesion, ECM interactions, immune response, hormone regulation, enzymatic activity, energy balance and neuronal structure & function were identified as key processes related to these proteins. The ProtAge score showed significant associations with 18 major chronic diseases, spanning CVD, metabolic diseases, organ-specific conditions, and cancer, as well as to all-cause mortality risk. Unlike recently described DNA methylation aging clocks, this protein-based score was strongly inversely associated with telomere length, a key cellular hallmark of aging. The authors concluded, “Our work demonstrates that development of proteomic aging clocks can be used as a reliable tool to identify biological mechanisms involved in disease multimorbidity and may serve as useful tools for identification of protein targets for possible drug treatment or lifestyle modification to reduce premature mortality and reduce or delay the onset of major age-related diseases and multimorbidity”. Read the article: https://lnkd.in/dvbzF8tp #proteomics #biomarkers #aging #populationhealth

Join us at the Olink Proteomics World Conference. This digital event features the latest advancements in proteomics and proteogenomics presented by esteemed scientists in the fields of immunology, oncology, neuroscience, ageing, and inflammation, among others. The event offers an opportunity to connect with peers, identify potential collaborations and learn about how advanced protein biomarkers’ discovery tools can easily be applied to your own research.

Exciting news! WuXi AppTec is now part of the Olink® Certified Service Provider Network for Olink® Target, Olink® Focus, and Olink® Flex! WuXi AppTec is a global company that offers R&D and manufacturing services for the pharmaceutical and life sciences industry. Through its unique business models, WuXi AppTec’s integrated, end-to-end services include chemistry drug CRDMO, biology discovery, preclinical testing and clinical research services, advanced therapies CTDMO, helping customers improve the productivity of advancing healthcare products through cost-effective and efficient solutions. Learn more about the Olink Certified Service Providers: https://bit.ly/4dCkSa8 #Olink #WuXiAppTec #ClinicalResearch #Pharma #Biomarkers #Proteomics #PrecisionMedicine #OlinkCertifiedServiceProviders