ONI

🔬 Only two more weeks for our #LiveFromTheLab! Get your Training Kit™ for dSTORM and join our session on the 12th of November. Already have your #TrainingKit? Sign up in here for our next Live from the Lab ➡️ https://lnkd.in/gs_Buzyv #SuperResolution #SMLM #microscopy #microscope #Biology #LifeSciences #Biotechnology #Imaging #dSTORM

🌟 Meet Anastasios Gkremos, Manufacturing Manager at ONI! 🌟 Anastasios embodies our core value: "We set a high bar." Here's Anastasios perspective on what this value means to him: "At the heart of every microscope we build is a commitment to exceptional quality. We take pride in our craftsmanship, knowing each instrument will empower scientific breakthroughs." Learn more about ONI and our company values here ➡️ https://hubs.li/Q02Wc69Y0 🚀 #STEM #SetAHighBar #ScienceImpact #CuriousMinds #SuperResolution #Microscopy #CoreValues

Today we highlight a recent work from the groups of Mathew H. Horrocks and Lynne Ragen from the The University of Edinburgh and the group of Sonia Gandhi from The Francis Crick Institute in London. The article titled Super-Resolution Imaging of Proteins Inside Live Mammalian Cells with mLIVE-PAINT, describes an innovative approach for #SuperResolution #imaging of live cells. The traditional #DNAPAINT approach relies on fixed cells, where proteins of interest are labeled with specific #antibodies that are fused to a single #DNA strand. Researchers then supplement the cells with a fluorescently-labeled complementary DNA strand. The annealing of both strands leads to a well-defined signal that can be recorded and analyzed. While this approach is a very useful #SMLM technique, it is not compatible with live cell imaging, as it requires both labeling with antibodies and the introduction of fluorescent DNA strands. Here, the scientists sought an alternative labeling method that is compatible with live cells: Instead of using antibodies, they engineered two sets of fusion proteins: The first, a fusion of their proteins of interest with a specific peptide; the second, a fusion of a fluorescent protein and another peptide, that partners with the first one. The fusion proteins are well tolerated by cells and they do not require any external labeling reagents, making them excellent candidates for #LiveCellImaging. The binding of the peptides concentrates the fluorescent protein around the protein of interest, allowing the scientist to record the precise cellular localizations with the #Nanoimager. Read the paper: https://lnkd.in/eK5rdAJG

Transform your #LNP research with #SuperResolution Microscopy! 🌟 Join us on November 20th for the webinar, “Why SMLM for LNP #Research?” 🔬 Discover how Single-Molecule Localization Microscopy (#SMLM) can provide critical insights and drive groundbreaking breakthroughs in your studies. Learn from our experts as they share innovative techniques that can elevate your research. Don’t miss this opportunity to enhance your understanding and gain a competitive edge—register now and take your research to the next level! 🚀 Register now - https://hubs.li/Q02VtVvr0 #LNPResearch #Webinar #Innovation #ResearchBreakthroughs #LipidNanoparticles #Biotechnology #Biotech #DrugDiscovery

🌟 It's #FluorescenceFriday and this week we are back with another chapter in the #HistoryOfMicroscopy: today we celebrate the 392 birthday of Antonie Van Leeuwenhoek, the pioneer microscopist who is considered by many as the father of #microbiology. 🔬 🔎 Van Leeuwenhoek was a Dutch politician and a draper, who took interest in lens-making in order to check the quality of the threads in his shop. He used his new lenses to construct a simple single-lens #microscope. Even though this wasn't the first microscope that was ever developed, the simple, yet, effective design provided a superior image quality to the ones previously made. Thanks to that, for the first time in documented history, Van Leeuwenhoek was able to see tiny moving objects, which he deduced were living creatures, later to be known as #microorganisms. 🔬 👨🔬 Following a series of letter exchanges with the Royal Society in London, the latter acknowledged that Van Leeuwenhoek has indeed discovered a whole new domain of life, today known as #bacteria and other unicellular organisms. Throughout his career he also identified and described many other microscopic entities, such as human cells, plant cells, #parasites, and others. Despite some skepticism in the early days, his evidence was convincing and his work was well recognized by the Royal Society and other distinguished institutions. It is hard to imagine the world of scientific #research without the innovative work of Antonie Van Leeuwenhoek.🌟 #HistoryOfScience #LifeSciences #SuperResolution #optics #microscopy #research

🌟 Are you at the GEIVEX Symposium 2024? Make sure you stop by and learn how ONI can take your #ExtracellularVesicle #research to the next level! 🚀 👩🔬 ONI's Laura Woythe, PhD and Peter Drent are ready to show you the #Nanoimager and the range of our specialty EV products - #EVProfiler2 and #AutoEV, which enable you to confidently explore your EVs at a single EV level! 🔬 #GEIVEX2024 #SuperResolution #SMLM #Microscopy #Microscope #dSTORM #SingleMolecule #Innovation #Research #Biotechnology #ResearchInnovation

We are so excited to attend this meeting! Make sure you stop by and check out our range of speciality EV products, including #EVProfiler2 and #AutoEV!

🌟 New to the world of grants and feeling a bit lost? You’re not alone! Navigating the research funding landscape can be daunting, but ONI is here to be your guiding light. We’re here to demystify the process, break it down into manageable steps, and empower you with the knowledge and tools you need to succeed. Check out our grants webpage for a step-by-step guide through the grants process, including a search database, tips, tricks, helpful timelines, and tools. Let's conquer this together! 💪📚 Learn more ➡️ https://hubs.li/Q02V3B5t0 #GrantWriting #ResearchFunding #SuccessInResearch #Grants #SuperResolution #Microscopy #CuriousMinds #Nanoimager #SMLM #Technology #Biotechnology #Biotech #Research #LifeSciences🔬

Are you coming to the Precision EV Forum 2024 meeting in Cambridge, UK? We have some more exciting events for you! 👩🔬 Tuesday, October 22nd, 3 PM BST - ONI, SCI-TIF and the CSI Imaging Facility are hosting live demos of the #Nanoimager. Let our experts show you how you can take your #research to the next level with our bench-top super-resolution microscope. Imaging Facility, Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Puddicombe Way, Cambridge CB2 0AW. Register here ➡️ https://hubs.li/Q02V3G6P0 🍻 Tuesday, October 22nd, 5 PM BST, Drinks, nibbles and networking. JCBC Foyer, Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Puddicombe Way, Cambridge CB2 0AW. Register here ➡️ https://hubs.li/Q02V3G6P0 Wednesday, October 23rd - Thursday, October 24th - find us at the Precision EV Forum 2024 meeting! 🌟 Our events are free to attend but prior registration is needed. Sign up now by clicking the links, scanning the QR codes, or simply by dropping a line to phillipa@oni.bio to let her know you'll be there. #PrecisionEVForum2024 #PrecisionEVForum #CambridgeTalks #CambridgeEvents #ExtracellularVesicles #Biotechnology #Innovation #SMLM #FRET #dSTORM #LifeSciences #StemCells

✨ Huge congrats to the Di Vizio Research Lab at Cedars-Sinai Medical Center for winning the 2024 EV competition! 🎉 As part of their prize, the lab will receive a complimentary ONI Nanoimager for three months to support their cutting-edge research on extracellular vesicles (EVs). 🔬 Led by Dolores Di Vizio, MD, PhD, the lab is pioneering investigations into the molecular mechanisms driving tumor progression in solid human cancers. Their work emphasizes intercellular communication and includes profiling large oncosomes and other EV populations using next-gen sequencing and mass spectrometry. Their research has been funded by the National Cancer Institute, Department of Defense, and Avon Foundation. A special thank you to all who participated in this year’s competition! Stay tuned for the 2025 EV competition, and get ready to compete! 💥 #ResearchExcellence #EVCompetition #Nanoimager #EVs #ExtracellularVesicles #ISEV