Promega UK

🔬 Spotlight on Speaker Sandra Prior, PhD at the 2024 Promega UK Biologics Symposium! We’re honoured to have Sandra Prior, PhD, from Medicines and Healthcare products Regulatory Agency (NIBSC) joining us to present on "Supporting Global Harmonisation and Traceability of Biologicals: The Role of Monoclonal Antibody International Standards & Reference Reagents for Bioassays". Sandra will discuss the vital role that International Standards play in harmonising bioactivity data for Biotherapeutic Monoclonal Antibodies. Her talk will explore how these standards translate proprietary units into international ones, ensuring consistency and regulatory compliance across different assay platforms. Sandra will also introduce the latest developments in reference reagents to characterise Fc-interactions, supporting global efforts in biologics traceability. 📍 Location: GSK, Stevenage, UK 🗓️ Date: 14 November 2024 Register for this free event at https://bit.ly/48pfBkq #BiologicsSymposium #MonoclonalAntibodies #Bioassays

How many types of RNA are involved in protein synthesis? The ghost whispers of three critical messengers that carry the code of life. Only when you discover their identities can you move forward. How many are there? https://bit.ly/3YFIDZW #PromegaHalloween

PARP and DDR Pathway Drug Discovery Exploring cancer therapy through DNA damage response (DDR) research? DDR is key for DNA repair and preventing genomic instability. Defects in this pathway can lead to cancer. Targeting kinases like WEE1, DNA PK, ATM/ATR, and PARP proteins is crucial in drug discovery. Promega offers advanced assays and technologies for PARP/DDR pathway research, including target engagement and cell health assays. Want to learn more? Visit: https://bit.ly/40kPpWo #kinases #PARP #assays

Next week join us in the Promega Halloween Escape Room: Solve the Molecular Mystery! Step into the eerie world of molecular science this Halloween with Promega’s “The Ghost in the Lab: Solve the Molecular Mystery” escape room! In the dead of night, a mysterious energy awakens the lab, and it’s up to you to solve the puzzles that will help you escape before dawn. A ghost haunts the lab, the victim of a scientific experiment gone wrong. Your mission? Unravel the mystery by solving puzzles related to protein synthesis, molecular structures, CRISPR, electrophoresis, and PCR. Answer each question correctly to uncover the code needed to escape the lab before the time runs out. Are you ready to take on the challenge? Starting on Monday, 28 October 2024, enter the escape room: Head over to any of Promega’s social media channels (Facebook, Instagram, LinkedIn or Twitter) Solve the daily questions: Use your scientific know-how to find the numerical answer to each question, posted every morning Monday, 28 October - Friday, 1 November. Get the daily code: Combine all your answers together to get the lock code and escape before 4.00pm (GMT) on Friday, 1 November 2024! Think you’ve got what it takes to escape the lab? Gather your knowledge, face the molecular puzzles, and see if you can solve the mystery in time. Lucky escapees will enter a draw to win a prize as will some of those sharing their progress on social media, tagging us in (UK and Ireland only) #PromegaHalloween

Forensic labs require efficiency and precision, especially when handling complex samples from sexual assault cases. Manual methods for differential extraction are time-consuming, and their performance can vary depending on the individual analyst. Optimise your DNA separation process with the Maxwell® DE System, designed for medium and high-throughput applications. Simplify the challenge of separating sperm DNA from mixed male/female casework samples to obtain single-source male STR profiles. • Automated, Consistent Results: Move beyond manual, user-dependent methods. • Familiar and Trusted: Leverage the Maxwell® Instrument you already trust. • Streamlined Protocol: Rely on Maxwell® for dependable results with casework samples. • Efficiency and Confidence: Experience reproducibility and reliability with every use. Let’s chat about how the Maxwell® DE Kit can elevate your forensic analysis More at: https://bit.ly/4eW8imG #STR #STRProfiles #DNASeparation

Bhindu Revi, Team Leader at RxBiologics said of Promega's Lumit "Promega’s #assays are robust, straightforward and give consistent results". 👉 https://bit.ly/3Ukd4lT #immunoassay #HTS #ELISAs

Join us at 4.00pm (BST) today for Day Three, the final day, of our 3 Day Virtual Event - Unlocking the Potential of RNA: New Paths for Targeting RNA - available free at https://bit.ly/4hjTAru Your Presenters on Day Three will be: • Amanda Garner, PhD, University of Michigan – Enabling Technologies for Revealing Druggable Paths in RNA Biology • Matt Disney, PhD, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology – Sequence-Based Design of Small Molecules Targeting RNA Structure Presentations will be followed by live, round-table discussion with presenters. #HTS #CRISPR #RNA

Join us at 2.00pm (GMT) on Wednesday, 30 October 2024 for our next free webinar - Does PowerPlex® 18E System Live Up to its Promise? Join our featured speaker, Prof Dr Katja Anslinger, as she provides results from her comparative tests to answer the question, does the kit live up to its promise? No other field of forensic medicine has developed as explosively in recent years as forensic molecular biology. New methods are constantly being developed, including special applications, which are intended to improve the processing of specific case constellations. Our group has been focusing with and on two such applications – both dealing with mixture deconvolution - for many years: The preparation of individual skin flakes from adhesive tapes as well as single cell DNA typing. The first is considered as one of the methods for finding the proverbial “needle in a haystack”, namely finding the one flake of skin left by the perpetrator in a huge majority of the victim's cells and often used in cold cases. Most skin flakes are of low DNA quality and quantity. Typically, profiles show (at best) pronounced ski slope effects but also allelic- as well as locus drop-outs were observed. Likewise, only partial STR profiles are usually obtained due to the very low DNA content of a single diploid or even haploid cell. Therefore, skin flakes and single cells are the ideal material to explore the potential and limitations of the new PowerPlex® 18E System. How does the kit perform compared to the PowerPlex® ESX 17 Fast, ESI 17 Fast and/or PowerPlex® Fusion 6C Systems used so far in our lab? In addition, what is the point of “the world’s shortest SE33” with an allele range of 170 to 310 bp? In this webinar, you will: - Understand the performance of the new PowerPlex® 18E System compared to other systems - Review real-world results from cold cases and blood mixture analysis using the PowerPlex® 18E System Register to save your place at https://bit.ly/3Uj1TtH #STRForensic #STR #ForensicMolecularBiology

🔬 Featured Speaker: Rosa Gonzalez Serrano at the 2024 Promega UK Biologics Symposium! We are excited to announce Rosa Gonzalez Serrano, Senior Manager at Abzena, will be presenting "Selecting the Optimal in vitro Assays to Assess Fc-mediated Effector Functional Activity" at Promega UK@ Biologics Symposium on 14 November 2024 GSK Stevenage, UK. Rosa will discuss the crucial role of Fc-mediated effector functions like ADCC, ADCP, and CDC in cancer therapeutics. Her talk will explore the key aspects of developing successful Fc effector functional assays and provide insights into the benefits and challenges of different assay formats. By reviewing options for target cell lines, effector cells, and controls, Rosa will offer guidance on selecting the most suitable assays for assessing therapeutic efficacy and safety. 📍 Location: GSK, Stevenage, UK 🗓️ Date: 14 November 2024 Register for this free event at https://bit.ly/3NDQm4g #BiologicsSymposium #FcEffectorAssays #ADCC

We hope you enjoyed Day One of our 3 Day Virtual Event yesterday. Join us later today, at 4.00pm (BST) Wednesday 23 October 2024 for Day Two - Next-Generation Therapeutics: The Power of Induced Proximity and Targeted Protein Degradation - available free at https://bit.ly/3NBqgyX Your Presenters on Day Two will be: • Fleur Ferguson, PhD, University of California, San Diego – Interrogating the Druggable Proteome with Proximity Pharmacology • Georg Winter, PhD, Center for Molecular Medicine of the Austrian Academy of Sciences – Identifying and Characterising Small-Molecule Degraders • Kristin M. Riching, PhD, Promega – Profiling ternary complex and degradation of CRBN neo-substrates • Zoran Rankovic, PhD, The Institute of Cancer Research London - PROTAC optimisation for oral delivery: How hard could it be? Presentations will be followed by live, round-table discussion with presenters. #Proteome #PROTAC #ProteinDegradation