Avidity Biosciences, Inc.’s Post

Advance your career at AstraZeneca, #cambridge UK as a #senior #scientist - #Protein Engineer in our #biologicsengineering team. This pivotal role involves isolating, optimising, and engineering #antibodies, #antibody fragments, and single domain #antibodies for our #therapeutic programmes. Utilise a variety of in vitro display platforms, such as phage, mammalian, RNA, and ribosome display, to drive innovation and support technological development within our Protein Engineering & Novel Modalities group. #joinus in our mission to push the boundaries of #science and make a difference in the world of #medicines. #biologics #followthescience #innovation #jobsearch #newcareeropportunities #sciencejobs #groundbreaking #lovewhatyoudo #greatplacetowork #greatplacetowork2023

Enhancing My Knowledge of Molecular Modeling and In Silico Drug Design I'm thrilled to share an important turning point in my career! I've been honing my skills in the cutting edge of in silico drug design studies for more than eight months. As a synthetic medicinal chemist, this field has expanded my knowledge and opportunities for understanding, contributing to, and love drug discovery and development. It is essential to pharmaceutical innovation. Having the ability to create molecular models is a prerequisite for comprehending the interactions and structural characteristics of possible therapeutic candidates. In Silico Testing: I can now simulate and examine the docking interactions between ligands and proteins, analyse the binding results, and generate publishable 2D and 3D images with ease. This testing is a powerful tool to decrease the compounds candidates for organic synthesis. The pharmaceutical industry is undergoing a revolution thanks to the faster, more cost-effective, and efficient drug discovery process made possible by the integration of in silico studies. The identification of possible therapeutic candidates is accomplished much more quickly thanks to computational techniques. Predicting drug behavior and interactions is more accurate by simulation. The entire cost of drug development is reduced when fewer early-stage laboratory experiments are required. The opportunities this presents for my professional path and the impact I can have on the pharmaceutical sector excite me. Using these cutting-edge methods not only broadens my skill set but also fits in with the industry's push for more creative and effective drug discovery procedures. I'd love to get in touch with other professionals who share my enthusiasm for in silico approaches and for pharmaceutical research and computational science. Let's collaborate, talk, and exchange ideas to push the envelope of what's conceivable in drug discovery! Image generated by PyMol. #InSilicoDrugDesign #MolecularModeling #PharmaceuticalInnovation #DrugDiscovery #ComputationalBiology #PharmaIndustry #ProfessionalDevelopment

💊🔬 Maximizing Drug Discovery Potential with BraCoLi: A Brazilian Innovation in Medicinal Chemistry 💊🔬 The application of computational tools as allies in drug design has marked a significant milestone in medicinal chemistry. This approach, known as computer-aided drug design (CADD), is widely used to optimize the discovery and design of new drug candidates. Molecular docking studies, structure-activity relationship (SAR) analysis, and virtual screening are a few examples of available computational approaches that can be employed in drug design. Currently, CADD data come from individual works available in the literature or on some websites. These strategies demand a large amount of chemical information to automate the screening of new bioactive compounds. Therefore, chemical databases were built as a resource to obtain this type of data more easily. They were designed to store, organize, and enable the search for readily available and quantitative information for biological applications, as well as physicochemical and molecular properties of ligands and targets. The process of building libraries is critical, as the data must be reliable to enable chemoinformatic experiments. It is important to emphasize that in silico approaches help and speed up the search for new bioactive compounds. This can reduce the number of compounds to be tested in in vitro and in vivo assays, anticipating suitable pharmacokinetic profiles, high selectivity, and low toxicity. Thus, virtual libraries contribute to increasing the success rate in the process of selecting new leads and gathering information parsimoniously, ensuring the quality, variety, and consistency of curated data. Inspired by these examples, the Brazilian Compound Library (BraCoLi) was built as a manually curated and open-access electronic database containing biological and chemical information of synthetic and natural semisynthetic molecules from Brazilian research groups. In this work, a description and a chemoinformatic characterization of BraCoLi based on chemical features and drug-like profiling, comparing with other databases, is presented. BraCoLi represents an innovative initiative in the drug discovery landscape, providing easy and free access to a rich collection of compounds developed by Brazilian researchers. Its manually curated resources and open approach encourage collaboration and the advancement of national and international pharmaceutical research. With its contribution to increasing the chemical diversity available for virtual screening and drug design, BraCoLi is playing a crucial role in the search for new therapies and treatments. Paper: https://lnkd.in/d3n5Bjum #DrugDiscovery #MedicinalChemistry #BraCoLi #BrazilianInnovation #PharmaceuticalResearch

Drug Discovery Market Outlook and Geography Forecast till 2031 !! Drug Discovery Market Size, Share & Trends Analysis Report By Process (Target Selection, Target Validation, Hit-to-lead Identification, Candidate Validation, Others), By Type (Medicinal Chemistry, Biology Services, Drug Metabolism, Pharmaceutical Services, Pharmacokinetics), By Therapeutic Area (Oncology, Neurology, Cardiovascular Disease, Respiratory Disease, Diabetes, Others), By Drug Type (Small Molecules, Biologics), By Technology (High Throughput Screening, Biochips, Pharmacogenetics, Nanotechnology, Spectroscopy), By End User (Hospital & Clinics, Pharmaceutical Companies, Biotechnology Companies, Research Institute, Global Economy Insights, Regional Outlook, Growth Potential, Price Trends, Competitive Market Share & Forecast, 2023 - 2031 🌐IMIR Market Research Pvt. Ltd. 📚 𝐆𝐞𝐭 𝐭𝐡𝐢𝐬 𝐒𝐚𝐦𝐩𝐥𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 👇  https://lnkd.in/dH83KMa6 📚 𝐓𝐨𝐩 𝐌𝐨𝐫𝐞 𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 𝐀𝐫𝐞:- 👇 Abbott., AbbVie Advinus Therapeutics Private Limited, Pune, Agilent Technologies. ALBANY MOLECULAR RESEARCH LIMITED Inc., Aria Pharmaceuticals AstraZeneca  Atomwise Aurigene Pharmaceutical Services Limited, Bayer  BenevolentAI BioAge Labs BioSymetrics BLEIB BERG HEALTH RETREAT Bristol Myers Squibb  Charles River Laboratories , ChemBridge Corporation,  Cloud Pharmaceuticals, Inc. Covance Cyclica Deep Genomics Eli Lilly and Company Envisagenics Euretos Exscientia F. Hoffmann-La Roche Ltd GNS Google Google DeepMind GSK  IBM Insilico Medicine insitro Merck Group.  Novartis NuMedii NVIDIA Taiwan Owkin Pfizer. #drugdiscovery #science #molecularbiology #medicinalchemistry #organicchemistry #research #electroniclabnotebook #chemicalregistrationsystem #chemicalregistration #cddvault #cdd #collaborativedrugdiscovery #eln #drugdesign #phd #womeninscience #phdcareer #reagents #pharma #molecule #drugsynthesis #orgchem #biochemistry #genetics #medicinalchemist #chemist #chemistry #biopharma #scicomm #laboratory

Bioinformatics and Cheminformatics Tools and Database for Drug Designing #biotech #bioinformatics #cheminformatics #drugdevelopment #pharma #chemistry

hiring！！Sr. Scientist (or Group Lead) in Protein Purification（蛋白质纯化高级科学家或组长） Responsibilities 1.Lead a 210 members team and be responsible for the production of antibody or protein reagents to enable external and internal discovery projects: Purify antibodies or different recombinant protein classes (e.g. secreted, soluble, membrane receptors or protein complex) from mammalian (293/CHO) transient/stable or non-mammalian (insect/e. coli) systems with multiple purification procedures. Characterize protein products using a variety of analytical tools to ensure quality control and proper protein attributes Collaborate with molecular cloning and expression teams to design plasmid vectors and purification strategies based on project needs 2.Project management and Team management: Identify project scopes, conduct literature study, design purification strategies, build timeline, leverage resources and coordinate upstream-downstream works in each protein production project or biologics discovery projects Interface with multiple function groups on project requirements, scheduling, execution, reporting and troubleshooting; ensure timely delivery and present status updates and results at internal and client meetings 关键词：#purification,# membrane protein#, #GPCR, #antibody, 蛋白纯化，抗体

Bioinformatics and Cheminformatics Tools and Database for Drug Designing #biotech #bioinformatics #cheminformatics #drugdevelopment #pharma #chemistry

#openposition for Researcher Uppsala University at the SciLifeLab Drug Discovery and Development Platform. To #stayinformed on the latest #jobopenings & #openpositions by #connecting with me on LinkedIn! #jobsearch #openpositions #Biotechjobs #microbiologyjobs #lifesciencejobs #MolecularBiologyJobs #careeroppurtunities #internship #studentship #researchjobs #careerhunt #Labopportunities #ResearchJobsNow #LifeSciCareers #clinicalresearch #opportunities2024 #postdoc

Global Automated Microbiology Market Size, Share & Trends Analysis Report By Product (Instruments, Automated Culture Systems, Microbiology Analyzers, Reagents), By Diagnostic Technology (DNA & RNA Probe Technology, DNA Sequencing, Detection Techniques, Non-Isotopic Methods, Radioactive Methods, Immunoassays, Monoclonal Antibodies), By End-Use (Clinical Laboratories, Biotechnology Industries, Others), Global Economy Insights, Regional Outlook, Growth Potential, Price Trends, Competitive Market Share & Forecast, 2023 - 2031. 🌐𝐈𝐌𝐈𝐑 𝐌𝐚𝐫𝐤𝐞𝐭 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐏𝐯𝐭. 𝐋𝐭𝐝. 𝐆𝐞𝐭 𝐭𝐡𝐞 𝐬𝐚𝐦𝐩𝐥𝐞 𝐫𝐞𝐩𝐨𝐫𝐭: https://lnkd.in/dNn_e43z 𝐂𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐰𝐨𝐫𝐤𝐢𝐧𝐠 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐚𝐫𝐤𝐞𝐭: Abbott Affymetrix. Agilent Technologies. Alere Inc. Avails Medical, Inc. Beckman Coulter Diagnostics BD Biolog, Inc. bioMérieux Bio-Rad Laboratories. Bruker Cepheid. COPAN Diagnostics, Inc. Danaher Corporation Don Whitley Scientific Ltd geneOmbio Technologies Hardy Diagnostics Hologic, Inc. InnovaPrep LLC Luminex MBIOLOG DIAGNOSTICO MEDISPEC Merck KGaA, Darmstadt, Germany Neogen Corporation PerkinElmer QIAGEN Rapid Micro Biosystems. Roche Diagnostics India, Neighbouring Markets S. Mentekidis S.A. SHIMADZU CORPORATION Siemens Healthineers SKAN Sysmex Corporation Thermo Fisher Scientific ZEISS Group #microbiology #biology #science #biotechnology #biochemistry #medicine #microbiologist #medical #laboratory #lab #molecularbiology #microscope #bacteria #microbiologia #pathology #neet #biotech #genetics #cellbiology #research #doctor #microscopy #chemistry #biologystudent #pharmacology #scientist #physiology #dna #anatomy #microbiologylab