Precision Medicine by Oxford Global’s Post

🔬 We are excited to announce that we support the Diagnostics-4-Future Conference in Kostanz on October 16-17, 2024. 👩🔬 👨🔬 We look forward to meeting you there and discussing everything from biomarker discovery to new developments of biomarker panels for clinical use and diagnostics. #Diagnostics4Future #Biomarker #Diagnostics #Sciomics #Precisionmedicine #Biotechnology

Come join the discussion!

Today we announced our collaboration with bit.bio, the company coding human cells for novel cures, which is aimed at 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝗶𝗻𝗴 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗮𝗻𝗱 𝗮𝗱𝘃𝗮𝗻𝗰𝗲𝗺𝗲𝗻𝘁 𝗳𝗼𝗿 #𝗗𝗠𝗗 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵. Thanks to the collaboration, Bi/ond has established protocols to generate and characterize human 3D #skeletalmuscle microtissues within its #MUSbit™ platform using opti-ox™ powered, defined and functional iPSC-derived ioSkeletal Myocytes™ and associated DMD disease model cells from bit.bio. 𝗧𝗵𝗲 𝗿𝗲𝘀𝘂𝗹𝘁 𝘀𝗵𝗼𝘄𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗸𝗲𝘆 𝗮𝘀𝗽𝗲𝗰𝘁𝘀 𝗼𝗳 𝗗𝗠𝗗 𝗽𝗮𝘁𝗵𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗶𝗻 𝗮 𝗵𝘂𝗺𝗮𝗻 𝟯𝗗 #𝗶𝗻𝘃𝗶𝘁𝗿𝗼 𝗺𝗼𝗱𝗲𝗹. As our CEO, Cinzia Silvestri stated: “𝙏𝙝𝙚 𝙥𝙧𝙤𝙢𝙞𝙨𝙞𝙣𝙜 𝙤𝙪𝙩𝙘𝙤𝙢𝙚𝙨 𝙤𝙛 𝙤𝙪𝙧 𝘿𝙈𝘿 𝙘𝙚𝙡𝙡 𝙚𝙭𝙥𝙚𝙧𝙞𝙢𝙚𝙣𝙩𝙨, 𝙘𝙤𝙣𝙙𝙪𝙘𝙩𝙚𝙙 𝙞𝙣 𝙘𝙤𝙡𝙡𝙖𝙗𝙤𝙧𝙖𝙩𝙞𝙤𝙣 𝙬𝙞𝙩𝙝 𝙗𝙞𝙩.𝙗𝙞𝙤, 𝙚𝙢𝙥𝙝𝙖𝙨𝙞𝙯𝙚 𝙩𝙝𝙚 𝙩𝙧𝙖𝙣𝙨𝙛𝙤𝙧𝙢𝙖𝙩𝙞𝙫𝙚 𝙥𝙤𝙩𝙚𝙣𝙩𝙞𝙖𝙡 𝙤𝙛 𝙟𝙤𝙞𝙣𝙩 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙚𝙛𝙛𝙤𝙧𝙩𝙨 𝙞𝙣 𝙖𝙙𝙙𝙧𝙚𝙨𝙨𝙞𝙣𝙜 𝙘𝙧𝙞𝙩𝙞𝙘𝙖𝙡, 𝙪𝙣𝙢𝙚𝙩 𝙢𝙚𝙙𝙞𝙘𝙖𝙡 𝙣𝙚𝙚𝙙𝙨 𝙨𝙪𝙘𝙝 𝙖𝙨 𝘿𝙪𝙘𝙝𝙚𝙣𝙣𝙚 𝙈𝙪𝙨𝙘𝙪𝙡𝙖𝙧 𝘿𝙮𝙨𝙩𝙧𝙤𝙥𝙝𝙮" If you want to know more about these results, and the 𝗰𝗮𝗽𝗮𝗯𝗶𝗹𝗶𝘁𝗶𝗲𝘀 𝗼𝗳 𝗕𝗶/𝗼𝗻𝗱 𝘁𝗼 𝗳𝗮𝗰𝗶𝗹𝗶𝘁𝗮𝘁𝗲 𝘁𝗵𝗲 𝗴𝗿𝗼𝘄𝘁𝗵, 𝘁𝗿𝗮𝗰𝗸𝗶𝗻𝗴, 𝗮𝗻𝗱 𝘁𝗲𝘀𝘁𝗶𝗻𝗴 of #3Dtissues, reach out to our team at info@biondteam.com so we can schedule some time together. Read more at: https://lnkd.in/e4WeBH2U and https://lnkd.in/ekNW9R-a #duchenne #duchennemusculardystrophy #dmd #gobiond #3dmodel #humancells #musculardystrophy #skeletal #ooc bit.bio

𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗵𝗶𝗣𝗦𝗖-𝗖𝗠 𝗺𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗧𝟯 𝗮𝗻𝗱 𝗗𝗲𝘅: 𝗔 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 🫀✨ Are you working with hiPSC-derived cardiomyocytes (hiPSC-CMs) and looking to improve their maturation for applications in disease modeling, drug discovery, or cell therapy? We've got something exciting to share with you! In collaboration with Bayer, Fraunhofer IBMT, and Hamamatsu Photonics France, we've developed an application note that dives into how triiodothyronine (T3) and dexamethasone (Dex) can enhance the structural and functional maturation of hiPSC-CMs. Our study combines impedance/EFP and calcium imaging to track calcium transients and electrical activity in the same cells. The results are promising, T3 and Dex not only modulate the electrical activity but also improve calcium handling, crucial for the maturation of these cells. We also explored how the NSP-96 transparent plate can be used for multiple assays, allowing you to measure electrical activity, contractility, and calcium transients from the same cell population using the CardioExcyte 96 and FDSS/μCELL. This means more data from fewer cells and reduced variability. Curious to learn more? Check out the full application note here: https://ow.ly/bwVS50T1NC4 #Cardiomyocytes #hiPSC #StemCells #DrugDiscovery #CellAnalytics #CardioExcyte96

#AmberGen is grateful for the opportunity to sponsor and exhibit at #IMSIS2024 in Münster, Germany. This is the premier annual event for the worldwide #MSI (Mass Spec Imaging) scientific community. Here I am visiting with Vaishnavi M.Natarajan, Ph.D and Marlien Kruse of Bielefeld University. Vai is a researcher who performs spatial metabolic profiling on a Bruker #timsTOF in her work. AmberGen’s Miralys(tm) MALDI HiPLEX-IHC is a perfect tool for scientists like Vai and Marlien who are already Mass Spec Imaging experts, and seek to take their research to the next level. #MSI is already the most multiomic imaging platform for #spatialbiology enabling imaging of small molecule drug distribution, lipidomics, metabolomics, untargeted glycomics, and peptidomics for biomarker discovery to be performed on tissue samples. AmberGen’s product enhances this by adding targeted proteomics, glycomics and transcriptomics to be added. What is remarkable is that all of this data can be collected using the same Maldi instrument, and amazingly on the same tissue sample. Tools like this will enable researchers like Vai to collect more information than ever before from their precious biological samples. Contact me at AmberGen to learn more. #IMSIS #multiomics #massspecimaging

🔍 Wondering why preclinical imaging should be on your radar? 💡 This video breaks it down for you! From unraveling intricate biological processes to accelerating drug development, preclinical imaging is your gateway to invaluable insights! With MOLECUBES, you can benefit from compact and intuitive imaging solutions with the highest performance supported by fast and simple workflows. State-of-the-art modular benchtop solutions from MOLECUBES make molecular imaging more accessible to a broader community of researchers in the field of preclinical drug discovery and development and fundamental and translational research. 👉 Ready to elevate your research game? Visit our website to learn more! #MolecularImaging #PreclinicalImaging #PreclinicalResearch

🌟 Exciting News from ProvaLabs! 🌟 We are thrilled to announce our significant contribution to groundbreaking research published in ACS Nano, where our proprietary TEER measurement technology played a crucial role. In this study, the ProvaLabs team provided precise quantification of transendothelial electrical resistance (TEER), enabling the detailed analysis of endothelial cell layer integrity in an innovative vascular phenotypic and proteomic analysis platform. This research not only highlights the impact of various antiangiogenic agents on cytoskeletal integrity but also underscores the importance of integrating quantitative metrics like TEER for comprehensive insights into angiogenesis and drug responses. 📌 Read the full article here: https://lnkd.in/gHNk9D5n A big congratulations to all the researchers involved! We're proud to be at the forefront of advancements in microphysiological systems. #Angiogenesis #TEER #ProvaLabs #ScalloP #Probe #QuantitativeAnalysis #CellCultureModel #QualityControl

Nanobodies are a game changer in PET and Fluorescence imaging. 💡 Derived from camelid species, like lamas and camels, nanobodies are small, unique antibody fragments, also known as VHHs (Variable Heavy-Chain Domains). Their single-domain structure makes them ideal candidates for targeting specific molecules with precision. What are we so excited about? Nanobody drug conjugates (NDCs) are emerging as a promising tool in molecular imaging, enabling precise visualization and tracking of specific biomarkers and molecular processes within living organisms. Advantages of nanobodies in Molecular Imaging: 1. High Specificity: nanobodies selectively bind to target molecules, minimizing background noise and enhancing imaging accuracy. 2. Rapid Targeting: their small size allows rapid penetration and binding to the desired location, improving imaging efficiency. 3. Nanobodies are well-tolerated by the body, reducing potential side effects. #molecularmonday #nanobodies #molecularimaging #drugdevelopment #antibody

At KCAS Bio, we're thrilled to announce the integration of Cytek's groundbreaking spectral technology into our service offerings. This cutting-edge advancement is a game-changer in the world of flow cytometry, and we're excited to share how it can transform your research. 🔬 Why Cytek's Spectral Technology? ·     Unparalleled Resolution: Experience high-dimensional data analysis with unparalleled clarity and detail. ·     Improved Sensitivity: Enhanced sensitivity can be beneficial for detection of dim or rare populations in your samples. ·     Maximize Your Data: Harness the power of full-spectrum analysis to extract more information from each sample. ·     Advanced Flexibility: Customize your panels like never before, with the ability to detect a broader range of fluorochromes. ·     Efficient Workflow: Simplify your experiments with easier panel design and faster data acquisition. 🚀 Elevate Your Research Whether you're exploring complex immunological landscapes, engaging in cancer research, or developing novel therapeutics, Cytek's spectral capabilities will elevate your research to new heights. 🔍 Our Expertise, Your Discovery At KCAS Bio our experts are ready to guide you through the advanced possibilities of spectral flow cytometry. Let us help you uncover the hidden potential in your research. 💡 Get Started Today Embrace the future of flow cytometry. Contact us to discover more about our Spectral Flow capabilities and how they can revolutionize your research journey. https://lnkd.in/gksXiyXp #ScienceAccelerated #SpectralFlowCytometry #Cytek #AdvancedCellularAnalysis #InnovateWithUs

🎉 Exciting news from Ora Biomedical, Inc.! They have been awarded $1.0 by the U.S. Department of Health and Human Services (HHS)  , The National Institutes of Health. This grant will support their innovative project, Elegantry, which aims to improve rigor and reproducibility in invertebrate research, specifically using Caenorhabditis elegans. This model organism is crucial for studying neuronal circuitry, cell development, and aging, but variability in reported lifespans has been a challenge. Ora Biomedical's solution will enhance data collection and automate key steps in the research process, ensuring more consistent and reliable results. #SBIR #STTR #BiomedicalResearch #Innovation 🔬 The award is part of the Small Business Innovation Research Program Phase I, and it will last for 12 months, starting from September 1, 2024, to August 31, 2025. Ora Biomedical's approach leverages high-throughput preclinical drug testing in non-mammalian models to identify compounds that extend lifespan and affect age-associated diseases. This project is set to revolutionize the field of aging research and drug discovery. #Longevity #HealthTech #ResearchFunding