HudsonAlpha Institute for Biotechnology’s Post

Insightful article about Prinses Máxima Centrum voor kinderoncologie researchers using BioSkryb’s PTA technology and machine learning to map the DNA of cells with hereditary diseases like Fanconi anemia. BioSkryb Genomics' ResolveDNA® and ResolveOME™ are changing the way that single cell technologies are used, creating new opportunities for discovery and translational research. These amplification technologies provide scientists with the capability to generate, analyze, and interpret much more pertinent data about complex diseases, revealing new groundbreaking discoveries. Read on to learn more about the work they’re doing: https://lnkd.in/ebFWbsSJ

📢 Conscience has released the results of CACHE Challenge #1, which aimed to predict "hits" for Parkinson's disease drugs through computational models. Conducted in partnership with The Structural Genomics Consortium (SGC) and funded by The Michael J. Fox Foundation for Parkinson's Research, the challenge has yielded seven promising discoveries for familial Parkinson's disease. The CACHE Challenge has two key outcomes: firstly, new discoveries that can help advance novel treatments for Parkinson’s disease, and secondly, prospective benchmarking of multiple computational methods to reveal the state-of-the-art and guide future progress. Conscience has now made the entire experimental dataset of the CACHE Challenge available to the public, including the chemical structures of all the molecules tested and associated computational methods. #Conscience #CACHEChallenge #ParkinsonsDisease #DrugDiscovery #ComputationalModels #OpenScience

A super interesting new paper titled, "The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation" has just been published. Click on the link below for details. #proteasome #science #ubiquitinationindependentdegradation https://lnkd.in/gT2gP4_V

"CRISPR's Next Advance is Bigger Than You Think" 💡 By Dr. Jennifer Doudna 🙌 Dr. Jennifer Doudna is an American biochemist who has done pioneering work in #CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing, and made other fundamental contributions in biochemistry and genetics. She was one of the first women to share a Nobel prize in sciences.  She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing". She is the Li Ka Shing Chancellor's Chair Professor in the department of chemistry and the department of molecular and cell biology at the University of California, Berkeley. She has also been an investigator with the Howard Hughes Medical Institute since 1997. 💡 In the video, she talks about how CRISPR has already cured sickle cell disease but it can help solve major problems like climate change. CRISPR can now be used to edit the entire population of #microbiomes. In humans, dysfunctional gut microbiomes are associated with Alzheimer's or asthma. In farm animals, microbiomes produce #methane, a major contributor to climate change. CRISPR + Metagenomics = Precision Microbiome Editing #CRISPR #metagenomics #geneediting #medicalsciences #climatechange

Research in focus 🔍 Problems with the structure and formation of the organs that make up our urinary system (including the kidneys and bladder) are an important cause of kidney failure in children. Although some of the changes in genetic information that can cause these issues are now known, in many cases an answer cannot be found. Dr Kathryn Hentges, Dr Mitra Kabir and Professor Adrian Woolf, from Manchester University, have used a form of artificial intelligence known as machine learning to identify new genes that might be involved in kidney disease.e This new study offers a chance to identify many unknown disease-causing genes in a time-effective manner, providing answers for kidney patients. There's further work to be done, but it can give hope to families living with genetic causes of kidney disease. Read more about the research 👉 https://bit.ly/3Zwyxta

Exciting Advancements in ALS Research 🧠, and it's a Canadian study 🇨🇦 Recent studies have brought promising news for those affected by Amyotrophic Lateral Sclerosis (ALS). A groundbreaking discovery has identified a protein interaction that could halt or reverse the progression of ALS. Researchers at Western University found that targeting the interaction between TDP-43 and RGNEF proteins significantly reduces nerve cell damage and improves motor functions in animal models. This breakthrough is a potential game-changer in ALS treatment: "In virtually all ALS patients, a protein called TDP-43 is responsible for forming abnormal clumps within cells, which causes cell death. In recent years, Strong's team discovered a second protein, called RGNEF, with functions that are opposite to TDP-43. The team's latest breakthrough identifies a specific fragment of that RGNEF protein, named NF242, that can mitigate the toxic effects of the ALS-causing protein. The researchers discovered that when the two proteins interact with each other, the toxicity of the ALS-causing protein is removed, significantly reducing damage to the nerve cell and preventing its death." Original article: https://lnkd.in/ekGqMxVN

Enhanced my skills in genomics research and biotech advancements through a hands-on course, mastering multiple sequence alignment, variant study, and phylogenetic analysis. Equipped to drive innovation in genomics and biotech applications. Open to exciting opportunities in this field! #Genomachub #GenomicsCourse #BiotechAdvancements #GenomicEvolution #MultipleSequenceAlignment #PhylogeneticAnalysis #GenomicsResearch #BiotechCareers #GenomicsInnovation"

#DNA | 𝗨𝗻𝗿𝗮𝘃𝗲𝗹𝗶𝗻𝗴 𝗔𝗻𝗰𝗶𝗲𝗻𝘁 𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗣𝗮𝗿𝗮𝘀𝗶𝘁𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗛𝘂𝗺𝗮𝗻 𝗚𝗲𝗻𝗼𝗺𝗲 | Led by Prof. Dr. Didier Trono, a team of scientists at EPFL (École polytechnique fédérale de Lausanne), made a groundbreaking revelation within the understanding of our genetic past. Their research, with resounding implications and possible applications, uncovers ancient genetic parasites within transposable elements (TEs) of the human genome. The methodological innovation behind this discovery involved reconstructing ancestral genomes in order to identify previously undetectable degenerate TEs. This papers the way for a deeper appreciation of evolutionary history and functional importance of these elements in our DNA. The potential for applications spans from diagnosing and treating cancer, autoimmune disorders, to metabolic anomalies and evaluating the body's response to environmental stressors and aging. Backed by the European Research Council (ERC), SNSF Swiss National Science Foundation, EMBO, and JSPS Overseas Research Fellowship, this novel exploration promises to impact therapeutic approaches and our comprehension of genetic influence on human diseases. 👉 Learn more >> https://lnkd.in/gt3eQ7i6 👉 Original publication >> https://lnkd.in/g3fEmWJf 🇨🇭 Follow #ScienceSwitzerland for the latest breakthrough news and emerging trends in Swiss science, technology, education, and innovation >> www.swissinnovation.org Follow us >> Science-Switzerland #Science | #Education | #Research | #Innovation

SCIENCE LEGEND OF THE DAY: Jennifer Doudna 🌟 Today, we want to celebrate Jennifer Doudna, a pioneering force in biochemistry and molecular biology. 🌿🔬 🔹 Who is Jennifer Doudna? Doudna is renowned as a co-developer of the CRISPR-Cas9 gene-editing technology, a groundbreaking tool that has revolutionized our approach to genetics. This technology enables precise modifications to DNA, opening up new possibilities for treating genetic disorders and beyond. 🔹 Why is her work significant? CRISPR-Cas9 is not just a technological advancement; it's a beacon of hope. This tool allows for accurate gene editing, with potential applications in curing genetic diseases, enhancing agricultural practices, and developing innovative therapies. 🔹 Achievements and Honors Jennifer Doudna’s contributions were globally recognized when she, alongside Emmanuelle Charpentier, was awarded the Nobel Prize in Chemistry in 2020. Her work continues to inspire countless researchers and drive forward the boundaries of science. 🔹 Impact on Society Doudna’s efforts highlight the transformative power of science. Through her groundbreaking research, she’s not only advancing our understanding of genetics but also paving the way for a healthier, more sustainable future. 🔹 Inspirational Quote "Science is a journey. We don’t always know where we’re going, but every step forward is one more piece of the puzzle." - Jennifer Doudna Let’s take a moment to appreciate Jennifer Doudna and all the visionary scientists who are shaping our world for the better. 🌍✨ #TodayWeCelebrate #Science #Innovation #Genetics #CRISPR #Biochemistry #NobelPrize #FutureOfScience

Discovering the Unseen: Groundbreaking Research Unveils 'Obelisks' in the Human Microbiome In a stunning revelation that broadens the horizons of microbiome research, scientists have uncovered a novel component within the human gut and oral microbiome: tiny RNA structures, dubbed 'Obelisks.' These entities, even smaller than viruses, carry genetic information capable of being interpreted by cells, introducing sequences previously unknown to science. This fascinating discovery, initially shared on the bioRxiv preprint server on January 21 and awaiting peer review, unveils obelisks as flattened circles of RNA. These structures are theorized to fold into rod-like shapes, marking a significant departure from known biological forms. While reminiscent of 'viroids' discovered in the 1970s, obelisks present unique genetic sequences, suggesting a new category of information-carrying molecules. The significance of this discovery extends beyond the mere expansion of our genetic catalog. It prompts a reevaluation of the intricate balance within the human microbiome, comprising bacteria, fungi, and other microorganisms. The presence of obelisks in nearly 10% of sampled gut and oral microbiota from a global dataset underscores their potential impact on human health and disease. This research not only rekindles the joy of scientific discovery but also opens new avenues for understanding the dynamics of life itself. As scientists delve deeper into the nature and function of obelisks, we stand on the brink of unlocking secrets that could reshape our understanding of the microbial world and its influence on human health. For professionals in the fields of microbiology, biotechnology, and healthcare, this discovery represents a thrilling frontier of exploration. The implications for diagnostics, treatment, and our comprehension of life's origins are profound. Stay tuned for further updates as this research progresses towards peer review and beyond. The journey into the unknown continues, highlighting the endless potential for discovery within the world of science. #MicrobiomeResearch #ScientificDiscovery #InnovationInScience #Healthcare #Biotechnology https://lnkd.in/eeMYWYux