INESC Microssistemas e Nanotecnologias’ Post

We are very pleased to see the result of the Focus Group Organ-on-Chip Standardization Roadmap led by NEN and CEN and CENELEC. The Focus Group was divided into different Working Groups and had the contribution of over 100 partners. 🤝 We were actively involved in the Working Groups related to Bioscience and Engineering. Our contributions to these working groups were two-fold: 1) Our close contact with end-users allowed us to bring real-world information to the roadmap discussions. 😎 2) Being involved with top-level discussions in Organ-on-Chip standards ensures our developments in microfluidics and control are state-of-the-art for our collaborators. ✅ This work can positively, and quite directly, impact projects such as H2020 Project ALTERNATIVE, LifeSaver Project, Tumor-LN-oC, BioProS, THOR Project EU and Bio-hhost. Overall, this Roadmap gives context and recommendations to orient the different initiatives and actors of the Organ-on-chip field. You can find it here 👉 https://lnkd.in/eWcd7huZ #organonchip #microfluidics #standardization #collaboration

🎯 EPFL TTO promotes Technology Offering for Licensing 📚💰 In today’s menu: iSort: #Automated #droplet manipulation in #microfluidic systems 💦 Current microfluidic systems enable precise manipulation of tiny #fluid volumes for various applications, from #medical #diagnostics to #chemical synthesis. However, they often face challenges in efficiently detecting, sorting, and manipulating individual sample objects due to limited #realtime control and feedback mechanisms. This limitation hampers the accuracy and scalability needed for advanced applications. 🌟Our innovative technology transforms microfluidic systems with enhanced real-time control and feedback, overcoming the limitations of existing solutions. Key Advantages ✨ 1. #Precise Control & Efficiency 🔍 Real-Time #Monitoring: Continuously monitor sample objects in both detection zones. #Feedback Control: Adjust manipulation parameters based on real-time data to ensure optimal performance. 2. Advanced Manipulation Techniques 🤖 Multiple Methods: Utilize #electrical, #optical, and #acoustic measurements to manipulate sample objects. Versatile Manipulation: Capable of deflecting, merging, or sorting objects with high precision. 3. Optimization & Stability 🔧 Efficiency Metrics: Determine and optimize manipulation efficiency through various parameters such as #voltage amplitude, #frequency, and #flow rates. Stability Metrics: Ensure consistent performance over time by continuously optimizing manipulation parameters. Potential Market for Licensing 🌐 The potential market for licensing this technology is vast and diverse, encompassing several high-growth industries: 1. #Biomedical #Research & Diagnostics 🧬 Lab-on-a-#Chip Devices: Revolutionize point-of-care testing with high precision and reliability. #Cell Sorting & #Analysis: Enhance the accuracy of cell sorting for research and #therapeutic applications. 2. #Pharmaceutical Development 💊 #Drug Discovery: Accelerate the screening of potential drug candidates through efficient microfluidic assays. #Personalized #Medicine: Enable precise manipulation of #biological samples for tailored therapeutic solutions. 3. #Environmental #Monitoring 🌍 #Water Quality Testing: Improve the detection and analysis of #contaminants in water samples. #Air Quality Monitoring: Facilitate the identification of airborne particles and #pollutants. Here ➡ https://lnkd.in/embihRFJ #technology #epfl #startup #technologytransfer #Innovation #Microfluidics #Biomedical #Diagnostics #Pharmaceuticals #EnvironmentalMonitoring Christoph Merten École polytechnique fédérale de Lausanne, EPFL The TTO team Andrea Crottini Mauro Lattuada Adam swetloff Natalia Giovannini Ghislain Singla Lucia Pavan Alberto D. Eric Meurville Bea Arnold Thomas Bourgeau

The exploitation of the potential of extracellular vesicles for any clinical application requires a detection method with high selectivity and low limit of detection (LOD). While nanozymes recently became a hot-topic for EV biosensing with their offerings in this set of requirements, the limitations of single-mode sensors pushed the researchers to seek dual-mode alternatives. Inspired by these ongoing developments, researchers from Nanjing University of Posts and Telecommunications developed a dual-mode EV aptasensor combining an electrochemical mode with a colorimetric one. Their approach, coupling the peroxidase-like activity of gold-platinum core-shell nanoparticles functionalized molybdenum disulfide nanocomposite with aptamer-based sensing, reached LOD as low as 9.3 particles/ml in the electrochemical mode and 4.2x10E3 particles/ml in the colorimetric mode. The further assessment of the capability of the approach for EV detection in human serum with >93% recovery suggests strongly that the approach is promising for accurate, sensitive, and selective biomarker analysis in clinical applications. For those interested in further reading: https://lnkd.in/djPCHRPW #exosomes #extracellularvesicles #EVbiomarkers #biosensors #aptamers #nanozymes

🔬SPIE, the international society for optics and photonics Photonics West 2024 trade show is in full swing, this week we present our topics on site in San Francisco and here on LinkedIn. Let's start with our marker-free #detection using #photonic #biosensors for #bio and #health applications. 🔍 Label-free detection methods - i.e. without additional reagents for molecular characterisation - have a high development potential as they can provide simpler diagnostic tools that can be used outside the laboratory and thus become accessible to non-specialist users. 🧬Fraunhofer IPMS is developing photonic label-free biosensors based on silicon nitride microring resonators in silicon technology. They are used for the selective detection of biomarkers or microbial substances and offer, for example, a suitable detection method for the early detection of diseases. 🔍💡 In collaboration with Fraunhofer IZI and Fraunhofer IOF we are currently developing a highly sensitive integrated photonic biosensor platform. Learn more on site or on our website: https://lnkd.in/evMjVZcF 👩💼👨💼 For you on site: Jan Grahmann, Thilo Sandner, Peter Dürr, Florenta Costache, Michael Scholles, Heinrich Grüger and Sara Francés #Biosensors #SensorTechnology #Biotechnology #Bioelectronics #MedicalDevices #SensingTechnology #HealthTech

This is a quick look part2 of J-OCTA. J-OCTA is a multi-scale simulation software for the analysis of phenomena on a wide range of scales from the atomistic scale to the micron scale. The target scale of the Full-Atomistic Molecular Dynamics (FAMD) is roughly about 10 nm. This approach models all the atoms that constitute molecules. It can be used to understand the thermodynamic behavior of molecules or crystals in materials and life science fields.  You can find many case studies for materials design, drug discovery and formulation. >>J-OCTA case studies https://lnkd.in/gfyzB6Fz #molecularmodeling #moleculardynamics #FAMD #simulation

Today we are showing how fast it is to reproduce a design, here we have the microfluidic gradient generator from Dr.Yu-Hsun Wang (Taiwan)! 🧪 This study delves into Christmas-tree-like MGGs, offering precise control over concentration gradients. The focus? Achieving uniform flow rates across all outlets to ensure consistent fluidic shear stresses on cultured cells. Simulation results recommend optimizing vertical channel lengths and tweaking horizontal channel partitions for optimal results. Experimental validation using PMMA-based microfluidic chips confirms perfect linear gradients. This design rationale is a game-changer for constructing ideal MGGs in cell-based applications, from chemotherapy to drug screening. 🚀 DOI : https://lnkd.in/eydPExx8 Take your guess, how much time it will take you to do this design with FLUI'DEVICE ? #Microfluidics #CellStudies #Innovation

Clene Nanomedicine, Inc.'s NIH-funded #ActEAP (Expanded Access Program) for #CNMAu8 in #ALS was recently highlighted in Bionews, Inc.'s ALS News Today by Margarida Maia, PhD. Learn more about our collaborative #EAP with Columbia University and Synapticure Inc. that will collect real-world data from 80% more participants: https://bit.ly/45gqVxV #EndALS

Researchers have developed aptasensors based on silicon nanowire field-effect transistors (Si NWFETs) for the electrical detection of thrombin, a model biomarker. Using a conventional top-down CMOS process, the Si NWFETs were co-integrated with CMOS readout circuits. EHTES organosilane was used to graft aptamer probes onto the Si nanowires. The study evaluated the impact of aptamer grafting and thrombin recognition on the electrical transfer capabilities of Si NWFET aptasensors. Aptamer grafting increased the threshold voltage, while thrombin recognition resulted in a negative shift. The findings demonstrate the potential of Si NWFETs for biomedical and biosensing applications. Source: https://lnkd.in/dhaGW_tK #biomarker #aptasensor #thrombin #medical #biotech

#VIBTechnologies is supporting VIB researchers with state-of-the-art #technologies supported by expert #technologists 👩🔬🧑🔬. This includes strategic #partnerships on cutting edge technologies not (yet) available in house. 💦 To support the growing demand in #research questions requiring custom #microfluidic devices, VIB has set-up an institutional collaboration with the biosensors group of Jeroen Lammertyn (special kuddos to Iene Rutten). Current applications range from 🌱 #root #development, studying #protein #aggregation over 🦠 #microbial applications and 🔬 multimodal #imaging. Interested in more? 👉 https://lnkd.in/e85gr6XX More on #VIBtechnologies? 👉 https://lnkd.in/eCwjvu9K

#Review Recent Advances in Field Effect Transistor Biosensors: Designing Strategies and Applications for Sensitive Assay by Ruisha Hao, et al. https://lnkd.in/eAdmU6-R MDPI Tianjin University #fieldeffecttransistor #biosensors #microfluidics #multiplexing #integration #openaccess #Abstract In comparison with traditional clinical diagnosis methods, field–effect transistor (FET)–based biosensors have the advantages of fast response, easy miniaturization and integration for high–throughput screening, which demonstrates their great technical potential in the biomarker detection platform. This mini review mainly summarizes recent advances in FET biosensors. Firstly, the review gives an overview of the design strategies of biosensors for sensitive assay, including the structures of devices, functionalization methods and semiconductor materials used. Having established this background, the review then focuses on the following aspects: immunoassay based on a single biosensor for disease diagnosis; the efficient integration of FET biosensors into a large–area array, where multiplexing provides valuable insights for high–throughput testing options; and the integration of FET biosensors into microfluidics, which contributes to the rapid development of lab–on–chip (LOC) sensing platforms and the integration of biosensors with other types of sensors for multifunctional applications. Finally, we summarize the long–term prospects for the commercialization of FET sensing systems.