Syncell Inc

Microscoop, an innovative microscopy platform, is designed to fill the needs of identifying novel protein constituents at the protein-protein interaction level. Existing mass spectrometry-based unbiased methods often lack subcellular spatial precision or sensitivity for high-precision proteomic discovery, both for cell and tissue samples.  Our solution is "optoproteomics," a cutting-edge technique that combines microscopy, mechatronics, photochemistry, and advanced image processing (either deep learning or traditional methods) to enable ultrahigh-content in situ photo-biotinylation. The Microscoop system photolabels proteins at user-defined regions of interest (ROIs) under a microscope, utilizing directed photochemistry one field of view (FOV) at a time for tens of thousands of FOVs with similar morphological features. Here’s how it works: 1) Microscopy Integration: The system uses advanced microscopy to visualize and define ROIs within cell or tissue samples. 2) Directed Photochemistry: Utilizing precise optics and photochemistry, the system photolabels proteins within these ROIs at 240-nm resolution. 3) High-Throughput Capability: This process is repeated across tens of thousands of FOVs, overcoming protein amplification problem by protein accumulation. 4) Extraction and Analysis: Photolabeled proteins are then extracted and analyzed via mass spectrometry, revealing both known and novel protein players specific to the ROIs. Read more - https://lnkd.in/gMpAv3ax #Syncell #SyncellTechnology #Optoproteomics

Our Syncell team recently took a break from the usual work routine for a fun and productive team-building day! New and existing members connected over various activities and bonded as they worked together on carefully crafted challenges. We also took the opportunity to celebrate our August birthdays together. It was a fantastic day filled with teamwork, laughter, and a stronger sense of community as we continue to grow rapidly. Here's to more moments like these! 🎉 #TeamBuilding #Syncell

Discover the future of protein extraction in our blog as we delve into the innovative realm of Laser Nano-Pulldown (LNP) technology. While laser capture microdissection has served as a cornerstone in cellular research, LNP emerges as a transformative approach, setting a new benchmark for precision and efficiency.    🎯 Precision at the Heart of Discovery  LNP targets proteins within discrete cell components or subcellular domains. Our technology doesn't just facilitate observation – it isolates with the finesse required for organelle-level molecular analysis.    🌟 Why Choose LNP by Microscoop?  - Enhanced Precision: LNP's laser accuracy and nanoscale process transcend traditional limitations.  - Organelle-Level Isolation: Distinct cellular territories for detailed study.  - Streamlined Efficiency: Achieve more in less time with Microscoop's advanced capabilities.    Read more : https://lnkd.in/gHgRcn-M #SyncellMicroscoop #LaserNanoPulldown #ProteinPurification #Microscoop

We're excited to announce the appointment of Philippe Lyko as Chief Financial Officer (CFO) and Nikhil Rao, PhD, as Senior Vice President of Commercial. Their experience and vision will be key as we drive Syncell into its next phase of growth and commercial success. Read full article - https://lnkd.in/eHfWrehe #SyncellTeam #Hiring #Proteomics

We're thrilled to present our latest webinar, where we explore the innovative Microscoop methodology. This groundbreaking technology enables high-precision spatial proteomic discovery through microscopy-guided protein photo-biotinylation. Our founder and CEO, Jung-Chi Liao, discusses the inspiration behind Microscoop's development and explains how the system integrates image processing and AI to achieve unbiased proteomic discovery. This advanced platform provides researchers with the tools to explore complex cellular structures with unprecedented detail.   Watch full video here: https://lnkd.in/ghAQv9-T   #SyncellMicroscoop #SpatialProteomics #ProteomicDiscovery #MicroscoopMethodology

Syncell is seeking talented individuals to join our dynamic team as we combine Taiwan's strengths in instrument development and manufacturing with international sales expertise. Our mission is to establish Syncell as a global leader in the proteomics instrumentation market through our technology. Founded in 2020, Syncell has grown to a team of over 60 industry experts, integrating microscopy, optics, mechatronics, photochemistry, and AI deep learning to commercialize the Microscoop® system, the world’s first "pickable" microscope. This revolutionary technology can detect previously unknown proteins with clinical value, overcoming current limitations in spatial proteomics. Explore career opportunities with Syncell and join a team that is pushing the boundaries of scientific discovery and making significant contributions to biomedical research. Current openings are based in our Taipei site. For those interested, reach us at info@syncell.com. #JoinSyncell #CareerOpportunity #BiotechJobs #Proteomics

Syncell is pleased to announce our attendance at the FASEB Molecular Metabolism: Cells and Systems conference. We will be showcasing our research poster titled "Identifying novel peri-droplet-mitochondrial interface proteins of oleic acid-treated HepG2 cells using microscopy-guided subcellular spatial protein purification." This presentation highlights our innovative approach and the capabilities of Microscoop technology in identifying previously unrecognized protein constituents at the mitochondria-LD interface, paving the way for further functional examination associated with lipid regulation and Non-alcoholic fatty liver disease pathogenesis. Connect with our scientist Yen Ming Lin. The conference covers a wide range of important topics, such as emerging methods for analyzing the compartmentalization of metabolism at the cell and tissue levels, the latest advances in regulating metabolic physiology and organ crosstalk, outstanding questions and current areas of research in targeting GLP1, and how metabolites can function as signaling molecules. We look forward to participating in insightful discussions and networking with fellow researchers at the FASEB Molecular Metabolism: Cells and Systems Conference. #Syncell #MolecularMetabolism #FASEB2024 #MMCSRC

Misfolded protein aggregates are a hallmark of neurodegenerative conditions like Alzheimer's, Parkinson's, ALS, and Huntington's disease, creating toxic environments that drive disease progression. For example, Alzheimer's disease is marked by β-amyloid plaques and tau tangles that disrupt brain function, while Parkinson's disease features α-synuclein aggregates known as Lewy bodies. Understanding these protein aggregates is crucial for developing effective treatments for these challenging conditions. The blog explores a new spatial proteomics discovery technique that enables researchers to pinpoint the exact location and composition of protein aggregates within diseased tissues. Read more - https://lnkd.in/gEjdyz6E

Syncell is set to attend FENS Forum 2024 in Vienna, Austria. Our team is eager to share, learn, and collaborate with the neuroscience community. We invite you to meet us at booth #403B to uncover new perspectives on the challenges facing our field. 📍 Booth #403B Hall B Ground Level #FENS2024 #Neuroscience #Syncell #ProteomicDiscovery