Deep Science Ventures

Really fantastic article by Karen Spink, Head of Medicines at Innovate UK, on the current landscape for childhood cancer therapeutics. Not to mention the fact that she says really very complementary things about the report we wrote together... 👀

We're #hiring a new Engineer, Constant Clean Power (mid to senior level) in Greater London, England. Apply today or share this post with your network.

🚨Hiring Alert🚨 We are developing a technology to cure paediatric cancer and prevent any future re-emergence and recruiting a co-founder to join the team to do this. Our approach harnesses the childhood immune system and re-targets it against tumours - flipping what has been a historic oversight (assuming that children are just "mini adults"). This comes on the back of our white paper with Innovate UK earlier in the year, during which we conducted a systematic exploration of the solution space. Please do help us amplify the opportunity - it could be someone's absolute dream job. Both the opportunity and the white paper are linked in the comments!

Announcing both the creation and pre-seed round of Kairos Carbon, led by Zero Carbon Capital! Kairos sets out to do for wet waste what biochar does for dry biomass, creating a >1000y permanent carbon removal pathway through a hyper-efficient, advanced hydrothermal processing system to break down waste. Kairos has an approach that: - Can plausibly achieve <$50 /tCO2t by leveraging the efficiencies of natural CDR and the quality of engineered CDR - Is extremely energy efficient (<100kWh/t, with the potential to be energy positive) - Can recover 100% of carbon (in contrast to hydrothermal carbonisation, torrefaction, fast or slow pyrolysis - all of which recover only part of the carbon) - Ensures >1000y permanence - Works with wet biomass of any water content (in contrast to e.g. pyrolysis which requires <25% water content) - Works with any bio-based feedstock including sludge, manure, paper pulp, food waste… (in contrast to chars and pyrolysis which typically require wood) - Produces clean water (in contrast to e.g. DAC which typically consumes water) - Destroys toxic ‘forever’ pollutants like PFAS - Recovers valuable inorganics like phosphorous Kairos's website and post announcing the round in comments! Congrats to Daniel Murray, Megha Raghavan, the DSV Climate team Noah Geeves, Adam Tomassi-Russell, Pina Fritz, PhD and the exceptional folks at ZCC for seeing the potential, Sarah Jones, Pippa Gawley, Alex Gawley and our friends at The Grantham Foundation for the Protection of the Environment for seeding the work Kevin Tidwell, Cyril Yee, Sam Lefkofsky, Elena Cavallero

Contemplating the yawning chasm between the first of a kind (FOAK) climate projects we need and those which are actually built, Mo Niknafs, Ahmad Butt, Noah Geeves and the DSV Climate team reached the conclusion that many are waking up to: we've hit a critical bottleneck. And whilst there's a good chance the FOAK chasm isn't the only thing yawning as we direct your focus towards climate finance; financing and building the first industrial instantiation of a frontier technology is a feat that we need to do at far higher frequency in fields as varied as high temperature heat electrification, CO2 storage, synthetic hydrocarbons. Running construction of largescale novel technology projects to time and budget is a specialised skillset that many Climatetech companies struggle to obtain. It is for this reason that we have partnered with some of the most incisive experts in the world on systemic analysis and ecosystem development in Climate - RMI and Third Derivative - to create Mark1 with founding backing from visionaries at Builders Vision and led by the extraordinary Julian Ryba-White. Mark1 is a developer-as-a-service for capital intensive, first of a kind climate projects. The Mark1 team are project development veterans focused on massively reducing the risk for Climate tech companies attempting to get their first project financed by taking on the execution of DevEx milestones equivalent to front-end loading 2. An article with more detail and a link to Mark1's website in comments, where you can register your interest for the service today. cc: Rushad Nanavatty Adam Tomassi-Russell James Lindsay Erin Livesey-Becks Dominic Falcão

Here's an opportunity to co-found a company with David, a former director at Moderna, designed in collaboration with Pharmaceutical giant Abbvie and DSV. One of the most ambitious and exciting projects we've developed yet and on such a unique and fascinating problem:

🚨 Hiring Alert 🚨 We are searching for a visionary and technically proficient co-founder to join forces with Eric Wasson Burns (Dr. sc. ETH Zurich) and lead the development of a groundbreaking in-situ mineral extraction technology. This venture will facilitate the mining of critical minerals, essential for the sustainable energy transition, without the need for traditional excavation or ore crushing methods. Our initial target market is nickel from lateritic deposits, but the technology has the potential to be adapted for other critical minerals in the future. 🚀

Announcing today the spinout of HyperCIM, an in-memory computing company founded by Dr Tanya Mangoma and joined by CTO Martyn Gilbert 🎉 The team designed HyperCIM to specifically increase the efficiency of some of the most performance-critical database workloads crippling potential clients working in real-time systems. The market for database management chips is >$90bn and HyperCIM’s hardware targets unnecessary time and energy wasted shuttling data back and forth between memory and processing elements in conventional designs with a demonstrated power performance improvement of 150x vs best-in-class standards. HyperCIM is collaborating with Arm and imec to deliver their first silicon prototype based on TSMC foundry-ready technology in 2025. This rapid progress from concept to mass-produceable prototype, usually so tricky in semiconductors, was possible because HyperCIM is not a discovery; it is an invention, purposefully designed from day one through our systematic venture creation process, with the requirements for success at scale built in through the careful stewardship of Ashraf Lotfi, Jamie Urquhart and Brock Doiron in partnership with Anglo American and through participating in the brilliant Chip Start programme run by Silicon Catalyst.UK. If you're interested in learning more about the company and their upcoming fundraising plans, please DM directly and please do tag or share with anyone you know interested in radical semiconductors innovation!

Announcing a new project in probabilistic computing, backed by the Advanced Research + Invention Agency (ARIA). Shannon Egan, Brock Doiron and Ashraf Lotfi proposed a radical new approach to probabilistic computing using the intrinsic properties of hardware itself. Very often, we ask computers to model probabilistic processes. This is a surprisingly inefficient process - asking machines designed for deterministic, binary operations to create random, more analogue outputs. In fact, much of computation's history has been spent trying to suppress the randomness of the physical world to avoid errors and 'noise'. The approach developed by Shannon, Brock and Ashraf flips a 'constraint' in computing, the rich, underlying randomness of physical devices, into an enabler of highly efficient probabilistic computing. The team, selected as one of 6 (so far) from 270 applicants across two rounds, will work with Suraj Bramhavar, a Programme Director at ARIA, as part of his opportunity space 'Nature Computes Better'. More in a link in comments.

Lots of open Founder opportunities at DSV right now, whether you care about water security (working with the awesome Brad S. Roan, PE), neurodegeneration (working with our incredible Pharma team - Kerstin Papenfuss, PhD MBA, Laura Fletcher, PhD, Jonathan Cohen-Gold, PhD and Anís Gammage fresh from three recent new companies this year so far with Plurify, OligoTune and Panthura) or decarbonisation of manufacturing with the indomitable serial founder Peter Kasprowicz)! Please do tag anyone who you think might be interested. Links in comments!