eBioMedicine – The Lancet Discovery Science

The March issue of eBioMedicine is live! On the cover this month... ✒️ Editorial: #Adenomyosis: an underacknowledged cause of abnormal uterine bleeding and pelvic pain 🗨️ Original Research: Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination 🧠 Review: Extracellular vesicles: new horizons in #neurodegeneration These articles, and more, can be read #openaccess on our website 👇 https://lnkd.in/eJyuBejt

📄🔬In back-to-back manuscripts, Drs R Jun Lin, Peter Zeng, Anthony Nichols, and the Canadian Airways Research Group reports on a large scale cohort study that identifies clinical, transcriptomic, and cellular features that define the rare disease idiopathic subglottic stenosis and its treatment outcomes. Their work helps pave a way forward for future clinical and mechanistic studies into this rare but devastating disease. Links to both studies in comments. 👇 #openaccess #rarediseases #translationalresearch #openscience

🩸Blood N-glycome profiling - a novel way to detect early Alzheimer’s disease?   The blood N-glycome is the landscape of N-glycan structures present on proteins in the blood. N-glycosylation is a common posttranslational modification found on proteins and has profound effects on protein function and localisation. Abnormal N-glycosylation of proteins has been implicated in several diseases, including Alzheimer’s disease. 🧠   A new study, led by Prof Lars Tjernberg at Karolinska Institutet and Karolinska University Hospital has developed a mass spectrometry-based method for N-glycome profiling in blood. Using this method, the authors show that decreased blood levels of a range of N-glycans are associated with Alzheimer’s disease. Furthermore, the decrease in these N-glycans could predict future cognitive decline in individuals without dementia.    Blood N-glycome profiling could be an early prognostic biomarker in Alzheimer’s disease. Read full #openaccess paper here: https://lnkd.in/eqNMix_m   #Alzheimer’s #Cognition #Dementia #Biomarkers #Glycosylation #Karolinska

Can pollution mapping predict chronic health issues? 🌍 New research from Boston Public Health Commission introduces aPEER (algorithm for Projection of Exposome and Epidemiological Relationships), a machine learning approach that uncovers geospatial connections between chronic diseases and exposure to environmental pollutants. 🔍 Significant associations were found between pollutants like acetaldehyde and formaldehyde with hypertension, stroke, and diabetes, highlighting their role in the well-known Stroke and Diabetes Belts in the southeast United States. aPEER produced over 68,000 interpretable maps, demonstrating superior predictive power compared to conventional health models. 🔮 These findings pave the way for targeted interventions to mitigate health risks associated with pollution and emphasise the role of exposures in understanding the pathogenesis of chronic diseases. Read the full #openaccess article in eBioMedicine! ⬇️ Link in comments ⬇️ #ChronicDisease #Pollution #MachineLearning #PublicHealth

🚀 Now online: Researchers from the University of Sydney and @Monash University Institute of Pharmaceutical Sciences have developed an innovative LNP-mRNA vaccine, mRNACV2, that enhances the immune response against Mycobacterium tuberculosis in a mouse model. Key findings: Induces high frequencies of polyfunctional Th1 CD4+ T cells. Enhances both innate and adaptive immune responses. Significantly reduces bacterial load in the lungs of infected mice. Effective as a standalone vaccine and as a booster to BCG. This research highlights the potential of mRNA technology in combating chronic bacterial infections like TB. 🌍💉 🔗 https://lnkd.in/esvMZ5QU #VaccineResearch #Tuberculosis #mRNA #Immunology #GlobalHealth

✨ Exciting new Lancet role ✨   This autumn, @The Lancet Group will launch an open-access journal dedicated to the unique health challenges on the African continent: The Lancet Regional Health—Africa.   To lead this important endeavour, we are searching for an Editor-in-Chief—someone with a good understanding of ✅ The challenges facing health care across Africa ✅ The dependencies and nuances within and between countries ✅ A well-established network of colleagues established during their time working in medicine or medical research   The Editor-in-Chief will ensure all content meets the rigorous standards of external peer review and that expected by our readers.   This will be a full-time, in-house position, based in Cape Town, South Africa.   Think you or someone you know is the ideal candidate? Find out more and apply here 👉 bit.ly/3Xp919w

A new CNS drug delivery method on the horizon? 🧠🐁 New research from Capital Medical University and collaborators explores a novel approach—intracalvariosseous (ICO) injection—for delivering drugs directly to the brain parenchyma through microchannels between the skull bone marrow and the dura mater, potentially expanding treatment options for stroke and other neurological disorders. 💉 This preclinical study demonstrated that ICO injection passes through the blood-brain barrier without compromising its integrity, with promising drug delivery efficiency and safety outcomes. Researchers used lower doses of neuroprotective agents than is used for intravenous injection and found that drug accumulation increased in the brain following ICO injection, as well as nerve damage repair and other markers of efficacy in rodent models of stroke. These findings provide hope for overcoming challenges in current CNS drug delivery methods, providing a foundation for future clinical research. Check out the full #openaccess article in eBioMedicine ! ⬇️ Link in comments ⬇️ #DrugDelivery #CNS #Stroke #Neuroscience 

🎙️Please check out this podcast where Professor Alisa Morss Clyne and Dr Callie Weber from the University of Maryland talk to Senior Editor Dr Gita Thapaliya about their recent article published in eBioMedicine examining the impacts of APOE-ε4 and exercise training on brain function and metabolism. Available on Apple Podcasts, Spotify and wherever you enjoy your podcasts! Link to podcast: https://lnkd.in/exNQ__Qt Full open access article: https://lnkd.in/e69xJj34 #openaccess #brainhealth #exercise 

Brains or Brawn - why not both? 🧠💪 New research from Karolinska Institutet and University of Gothenburg explores the hypothesis that body composition and muscle strength is correlated with brain function during ageing. 🔬 A study of 674 dementia-free 70-year-olds in Sweden found that higher muscle mass was linked to younger predicted brain ages, while higher visceral fat was associated with increased brain atrophy. Tests of physical function, such as walking speed and handgrip strength correlated with better brain health indicators, as measured by MRI. These important insights support further work into the effects of exercise on healthy brain ageing and could help to develop ways to protect against cognitive decline. Read the full #openaccess article at eBioMedicine! ⬇️ Link in comments ⬇️ #BrainHealth #ResearchCommunity #HealthyAging #Neuroimaging

🚨 New Research from #kuleuven published in eBioMedicine: "Interpretation of indoor air surveillance for respiratory infections: a prospective longitudinal observational study in a childcare setting". 🧒🏽🏫 This innovative research highlights the potential of indoor air sampling as a sensitive and non-invasive method for monitoring respiratory pathogens. Key findings include: 🔬 Air sampling detected most pathogens found in nasal mucus. 🌬️ Pathogen concentrations in the air correlated with the number of attendees with infections and CO2 levels. 📈 Air sampling could provide early warnings for outbreaks, complementing existing surveillance methods. Read the full paper for free 👇 : https://lnkd.in/ebwG_K9u #Research #PublicHealth #Epidemiology #AirSampling #RespiratoryInfections #Childcare #KULeuven #eBioMedicine