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#mostcited 🏆Recommending One of Our Most Cited Reviews in 2022 Q1！ 📚Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis 🔗https://lnkd.in/gCR4mcin 👨🔬By Prof. Piero Portincasa et al. Università degli Studi di Bari Aldo Moro Albert Einstein College of Medicine Ludwig-Maximilians-Universität München #molecular #endocrinology #metabolism #intestine #bacteria #metabolome #fiber #diet #glucosehomeostasis

Gingerol- Important Bioactive From Plants! Found in members of the Zingiberaceae family, gingerol is a phenolic compound that activates heat receptors on the tongue. When ginger is cooked, gingerol changes to zingerone, which has less pungency; however, when dried it forms shogaols, which are more pungent. Among its possible health benefits: ·     Anti-nausea ·     Prokinetic ·     Digestion ·     Blood Sugar Balance ·     Pain Relieving ·     Heart Health ·     Anti-Cancer ·     Antioxidant ·     Anti-inflammatory ·     Immunity Excitingly, gingerol has recently shown promise as a natural defense against autoimmune disease. In preclinical work, 6-gingerol, which is the most abundant phytochemical in the ginger rhizomes was shown to reverse impacts of neutrophil hyperactivity. Follow-up clinical investigation on humans found that ginger extracts, as well as whole herb consumption, could do the same in short periods of time and increase resistance to developing neutrophil (NETosis) autoimmune conditions, such as lupus. Ginger extracts have also been employed in Functional Medicine protocols for their prokinetic benefits, especially in the management of Small Intestinal Bacterial Overgrowth (SIBO). As SIBO is a known contributor to the development of intestinal permeability (“leaky gut”), which is related to development of autoimmune conditions, the role of Ginger continues to be clarified. Ginger has a history of safe consumption, and also has been long-used for improving digestion in traditional medicine. With these new developments in science its clinical use is poised to expand. #bioactives #medicinalplants #phytochemicals #ethnobotany #biodiversity #phytochemistry #Gingerol #ginger #autoimmune *This post is for educational purposes only. It is not intended to diagnose, cure or treat any disease. Always seek medical advice directly through consultation with a health professional.

Omega−3 fatty acids are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond, three atoms away from the terminal methyl group in their chemical structure. They play an important role in the human diet and in human physiology. An important omega−3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA can be found in plants, while DHA and EPA are found in algae and fish. Mammals are unable to synthesize these essential omega−3 fatty acids and can only obtain them through diet. However, they can utilise ALA, when available, to form EPA and DHA.

Who knew that Boron is of of the most important minerals on the periodic table ? For soil, food and human health. What is the leading cause of shortage of Boron ? Use of synthetic fertilzers reduces Boron levels in soil and thus our food : The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body’s use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor μ (TNF-μ); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin’s lymphoma... https://lnkd.in/gW8rGWxF.

Menthol- Important Bioactive From Plants! Menthol is a cyclic monoterpenoid found in mint (Mentha) species responsible for the minty taste of peppermint oil. It is known to have local anesthetic and weak k-opiod receptor agonist activity. Among its possible health benefits: ·     Pain Relief ·     Irritable Bowel Syndrome (IBS) ·     Antibacterial ·     Cold Symptoms ·     Antioxidant ·     Cancer ·     Anti-obesity ·     Antiinflammatory ·     Antidiabetic ·     Cardioprotective Excitingly, a number of clinical trials have found peppermint oil (which contains menthol) to be useful for the cramping, pain, and other symptoms of irritable bowel syndrome (IBS). A meta-analysis of pooled clinical data involving 12 randomized trials with 835 patients found peppermint oil to be safe and effective for the pain and global symptoms in adults with IBS. #bioactives #medicinalplants #phytochemicals #ethnobotany #biodiversity #menthol *This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician.

Are you sleeping on Boron ? One of the worlds most important mineral for agriculture, food and human health. A paper in NIH concluded : : Boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body’s use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as hs-CRP and TNF-α; (6) raises levels of antioxidant enzymes, such as SOD, catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves brain electrical activity, cognitive performance, and short-term memory in elders; (9) influences the formation and activity of key biomolecules, such as SAM-e and NAD+; (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers and multiple and non-Hodgkin’s lymphoma; and (11) may help ameliorate the adverse effects of traditional chemotherapeutic agents. Americans’ daily dietary intake of boron was estimated to be approximately 1 mg/d in 1999. In none of the numerous studies conducted to date, however, do boron’s beneficial effects appear at intakes of less than 3 mg/d.  https://lnkd.in/gW8rGWxF.

Check out our 5 top tips for recreating the digestive system in a parallel bioreactor system if you're interested in simulating the gastrointestinal tract! #Biotechnology #Bioreactors #Microbiology 👇https://hubs.la/Q02sdC4Q0

https://lnkd.in/gVX5tpQv   Article title: Preparation, production and characteristics of sugarcane vinegar   Author(S): Jyotsana Singh, Neha Bisht and Amar P Garg*   Journal: Journal of Biology and Medicine   Journal ISSN: 2688-8408 Abstract: Sugarcane is one of the main crops worldwide, and it has an important impact on environmental issues. Sugarcane is used in daily routine life in many ways like as vinegar, jiggery, juices etc. In India sugarcane crop is best cultivated in the west U.P. Sugarcane original vinegar drink with high nutritional quality was produced from fresh sugarcane juice using the yeast culture and acetic acid bacteria by fermentation techniques such as submerged alcoholic fermentation followed by acetic fermentation at room temperature. Refined sugarcane is the primary product of sugarcane juice, during its processing, various other valuable products are also obtained in an unrefined form such as brown sugar, molasses, jaggery and vinegar. Sugarcane juice is widely used in the treatment of jaundice, hemorrhage, dysuria, and other urinary disease. Nowadays sugarcane vinegar is also used in Indian kitchens commonly in pickles, salads, etc. Vinegar is extremely useful for human health including antimicrobial activity, blood pressure reduction, antioxidant activity, reduction in the effects of diabetes, and prevention of cardiovascular disease. Phenolic acid in vinegar can scavenge superoxide anion and free radicals in vivo resulting in a potent antioxidant activity. #Sugarcanevinegar #Yeastculture #Aceticacidbacteria #Diabetes #Cardiovasculardisease #Antioxidantactivity   #Biochemistry #Biotechnology #Bioinformatics #Cardiology #CellBiology #Peertechz #PeertechzPublications #FoodAndNutrition #FreeRadicalResearch #InfectiousAndCommunicableDiseases #Genetics #Gerontology #Microbiology #Hepatology #Gastroenterology #Toxicology #MedicinalChemistry #Nanotechnology #Oncology #Pharmacology #PlantBiology #Pathology #Physiology #RadiationBiology #Nephrology #StemCellResearch #VascularBiology

📃Scientific paper: Localization of EccA_3 at the growing pole in Mycobacterium smegmatis Abstract: Background Bacteria require specialized secretion systems for the export of molecules into the extracellular space to modify their environment and scavenge for nutrients. The ESX-3 secretion system is required by mycobacteria for iron homeostasis. The ESX-3 operon encodes for one cytoplasmic component (EccA_3) and five membrane components (EccB3 – EccE3 and MycP_3). In this study we sought to identify the sub-cellular location of EccA_3 of the ESX-3 secretion system in mycobacteria. Results Fluorescently tagged EccA_3 localized to a single pole in the majority of Mycobacterium smegmatis cells and time-lapse fluorescent microscopy identified this pole as the growing pole. Deletion of ESX-3 did not prevent polar localization of fluorescently tagged EccA_3, suggesting that EccA_3 unipolar localization is independent of other ESX-3 components. Affinity purification - mass spectrometry was used to identify EccA_3 associated proteins which may contribute to the localization of EccA_3 at the growing pole. EccA_3 co-purified with fatty acid metabolism proteins (FAS, FadA3, KasA and KasB), mycolic acid synthesis proteins (UmaA, CmaA1), cell division proteins (FtsE and FtsZ), and cell shape and cell cycle proteins (MurS, CwsA and Wag31). Secretion system related proteins Ffh, SecA1, EccA1, and EspI were also identified. Conclusions Time-lapse microscopy demonstrated that EccA3 is located at the growing pole in M. smegmatis . The co-purification of EccA_3 with proteins known... Continued on ES/IODE ➡️ https://etcse.fr/Lvx ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Source: The Journal of steroid biochemistry and molecular biology This study used liquid chromatography tandem mass spectrometry to measure phytosterols in human serum. Phytosterols are compounds found in plants that have similar structures to cholesterol. They cannot be produced by mammals and are obtained through diet. Phytosterols have been associated with various health benefits, including lowering low-density lipoprotein cholesterol, anti-inflammatory effects, and anti-cancer properties. The study developed a method for analyzing phytosterol content in human serum and found varying concentrations of different phytosterols in ten individuals. The methodology can be applied to analyzing other biological fluids and tissues.