Waters Corporation’s Post

In collaboration with Waters Corporation, Similis Bio demonstrated an automated Protein A purification and LC-MS analysis of bioreactor samples. The goal? To screen biosimilar monoclonal antibody (mAb) candidates and compare them to the innovator product during process development. The method proved sensitive and precise, allowing quantitative assessment of N-linked oligosaccharides and other post-translational modifications (PTMs). By evaluating these quality attributes early in clone selection, biopharmaceutical organizations can reduce subsequent development costs. The workflow also enables localization of Fab vs. Fc modifications. Read more about this innovative approach here: https://bit.ly/4dMci9f #Bioprocess #SimilisBio #biotherapeutics

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Introducing High Throughput BioResolve Premier Columns for rapid analysis of large biomolecules. Reduce chromatography run-times by up to 5x and obtain vital information about monoclonal antibody critical quality attributes to make development decisions – fast. Learn more--> https://bit.ly/3VYuhTG

Column Selections and Their Effects on Compact Capillary Liquid Chromatography Systems A study conducted by researchers at Rowan University explores column selection in compact capillary liquid chromatography (LC) systems. Link: https://ow.ly/1MM450PFWJc

Waters Announces Seamless HPLC/UPLC Data Bridge for Light Scattering, Integrating Essential Instruments for Large Molecule Characterization

Waters Announces Seamless HPLC/UPLC Data Bridge for Light Scattering, Integrating Essential Instruments for Large Molecule Characterization

Waters introduces seamless HPLC/UPLC data bridge for light scattering, integrating essential instruments for large molecule characterization

"Real-time" results⏱️, non-destructive analysis🩹, identification of molecular species🔬, inline process control👍 – Discover the Raman spectroscopy solutions from Metrohm Applikon | Metrohm Process Analytics: https://brnw.ch/21wJqN8 #Metohm #processanalysis #processmonitoring #processcontrol #industrialmonitoring #raman #ramanspectroscopy

Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF Characterization of oligonucleotides requires robust analytical instrumentation and methods as well as ease-of-use data analysis tools. Agilent 1290 Infinity II Bio LC System is made of biocompatible material for use with challenging mobile phase conditions in biopharma applications. Biocompatibility mitigates non-specific sample binding to flow path and it ensures the integrity of biomolecules and robustness of the system. The Target Plus Impurities (TPI) and Sequence Confirmation workflows in Agilent MassHunter BioConfirm software have already been introduced in two separate application notes.1,2 In this study, both workflows were carried out to characterize two oligonucleotide samples using Agilent 1290 Infinity II Bio LC System coupled to Agilent 6545XT AdvanceBio LC/Q-TOF https://lnkd.in/gga4kQNS

Sophisticated reaction monitoring and optimisation have never been easier. Kinetics is compelling with #ReactALL. This is a recipe for how to make formulation ideas come true. - A breakthrough concept 💡 - Scientists 👩🔬 👨🔬 - 5-10 mL of sample (ONLY) ⚗ - ReactALL - HPLC - Well written report 📄 It is never been easier. Technobis Crystallization Systems #chemistry #reactions #formulations #pharma #pharmaceuticals #laboratory #experiment #instrumentation #quantitative #particles #QC #QA