Sony Biotechnology Inc.’s Post

NEWS ALERT 👀 CLS just got a spotlight in the latest Axios story, "Silicon Valley's biotech sector is still going strong," featuring insights from our own Brent Fisk and data from our 2023 Sector Report! 📰 Read how the #lifesciences sector serves as an anchor for the local economy and challenges ahead: https://bit.ly/3rU5jYm

I am proud to share our work in #JMedChem for one-pot #PROTAC synthesis via photochemical C(sp2)-C(sp3) cross coupling and amide bond formation. In the paper you can find comprehensive scopes detailing the substrate tolerance of the photochemical C(sp2)-C(sp3) coupling on various CRBN binders and linker motifs. The one-pot synthesis grants rapid access to BRD4 PROTACs in a single step via heterobifunctinal linker building blocks. This might be useful to #MedChemists looking to overcome the synthetic hurdles of making a lot of #PROTACs fast for #drug discovery programs. You can read about our work in #JMedChem here: https://lnkd.in/eyCiE3HG and can find some nice illustrations of our #PROTAC factory on the cover of J. Med. Chem. as well. This project was a great collaborative effort between Boehringer Ingelheim and the University of Mainz. Many thanks to Christine Marie Arndt, Jacqueline Bitai, Jessica Brunner, Till Opatz, Paola Martinelli, Andreas Gollner and Kevin Sokol. Special thanks to Harald Weinstabl for funding these wild ideas that eventually turn into something useful for the daily work in drug discovery.

Listen to Liam Clifton and myself and learn about Quantum‘s approach to AI.

Iris Kinetics technology empowers scientists to explore complex binding interactions with precision, speed, and label-free convenience. Leveraging the power of #microarrays, in a single experiment (lasting less than an hour), researchers can characterize the binding affinities of small or large biomolecules to multiple probes. The technology is transparent to DMSO, resulting in clean binding data for small molecule drug candidates investigations. This approach is most powerful when a profile of binding affinities is needed. Visit us in Philly at #BPS2024 #axiVEND booth 709, you’re in for an exciting glimpse into the future for diagnostic applications! #m2automation #drugdiscovery 

We are counting down our top 3 biologics blog posts of 2023! #1 explores the novel use of mechanistic modeling in combination with Computational Fluid Dynamics (CFD). 👉 https://ow.ly/fM3n50QlmUs

This Friday (Sept 22nd at 11am ET) I will presenting a #GEN webinar titled Biochip Arrays and Mass Spec: More than Scratching the Surface for Drug Discovery. We will discuss how combining #surfacechemistry and #massspec enables a powerful, flexible tool for analyzing biochemical reactions and binding interactions in a #labelfree and #highthroughput manner to accelerate #drugdiscovery for virtually any target! https://okt.to/NFuW64

Explore the power of the Simcyp™ Simulator's extensive compound library, featuring 130 small molecule and 6 large molecule models. With detailed summaries, gain valuable insights into compound development, performance, and drug-drug interactions.   Discover a wealth of knowledge to enhance your PBPK modeling endeavors. Learn more: https://ow.ly/aIab50PifWu   #PBPKModeling #DrugDevelopment #Simulation #Pharmacokinetics #RegulatorySubmissions #SimcypSimulator #CompoundLibrary

ICYMI: XiFin, Inc. recently released its new Lab Volume Index. Check it out now for a closer look into post-pandemic diagnostic testing and monthly trends in volumes across various segments: https://hubs.li/Q025H49g0 #laboratory #molecular #revenuecyclemanagement #diagnostics #labtrends

Our patented assay ArrayPlex™ is uniquely able to generate hits by screening two libraries against each other without prior knowledge of ligand or target.    #microarray #highthroughput #drugdiscovery    https://lnkd.in/eadZi_NY

Did you miss any of our February news and highlights? Here is a comprehensive summary of our posts for this month: News & Conferences 1. Meet Olga Tarkhanova and Rita Gaidar at the 9th Fragment-based Drug Discovery Conference in Cambridge! 2. Also, Chemspace team will be happy to catch up at the Conformational Design in Drug Discovery in Stevenage. 3. Check out our Website Update - Discovery CRO page! #Meet_Chemspace_team: Meet Chemspace Team – Mariana Perebyinis, Data Scientist We continue our series of posts “Building Blocks for DEL”: Part 3. Bis(catecholato)silicates. New Library Sets & Updates: Our General Pre-Plated Library has expanded - now over 672,000 compounds are available for off-the-shelf ordering! Meet a new post in the “Chemspace products – Biologics for Research” series: Estrogen receptors (ERs). Building Block and Screening Compound Sets: Explore Analogs to New Biological Tool Compounds (Camizestrant). Weekend article and corresponding service: Shape-Aware Synthon Search for virtual screening of synthon-based chemical spaces. There is a NEW SUPPLIER this month: RR Scientific LLC. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures