The Journal of Clinical Investigation’s Post

🔬 Recent studies have explored the molecular architecture of heart failure (HF). 🫀 Researchers are now turning to extracellular vesicles (EVs) as a potential "liquid biopsy" for HF. These tiny structures transport proteins, DNA, and RNA between organs, providing valuable insights into disease status and multiorgan function. Exciting findings reveal distinct RNA profiles in EVs between HFpEF and HFrEF, offering new possibilities for personalized management. 💡 #HeartFailureResearch #ExtracellularVesicles #LiquidBiops Saumya Das https://lnkd.in/g4SGX39V

2️⃣5️⃣ years of Research and Innovation in Cardiac Arrhythmias 🫀⚡️ condensed in one amazing #Europace issue. Don’t miss the chance to get up to date on 💠 Cardiac pacing and Resynchronisation 💠 Atrial Fibrillation 💠 Sudden Cardiac Death 💠 Syncope 💠 Cardiac Imaging for arrhythmias 💠 Arrhythmias in cardiomyopathies and genetic disorders https://lnkd.in/e2k3eSNx

An intriguing mechanistic study exploring therapeutic inhibition of lincRNA-p21 just published in Circulation Research sheds light on the functional significance of stress-induced long noncoding RNA in cardiac hypertrophy and demonstrate the potential of lincRNA-p21 as a novel therapeutic target for cardiac hypertrophy and subsequent heart failure https://lnkd.in/dQXY5Qmt

In a recent highlight from our webinar, "Unlocking Genetic Causes of Sudden Cardiac Death with Scalable Assays of Variant Effect," Dr. Victoria Parikh provided an insightful answer to an important question about utilizing assays of variant effects To hear Dr. Parikh's response and explore more about how scalable assays are transforming our approach to cardiac genetics, click the link to view the entire session. Don't miss these expert insights into advancing precision medicine in cardiology! Watch the Full Webinar Here: https://lnkd.in/d5BFGbn3 #CardiacGenetics #PrecisionMedicine #Webinar #MAVEvidence #ConstantiamBiosciences #polygenicconditions

In a recent highlight from our webinar, "Unlocking Genetic Causes of Sudden Cardiac Death with Scalable Assays of Variant Effect," Dr. Victoria Parikh provided an insightful answer to an important question about utilizing assays of variant effects To hear Dr. Parikh's response and explore more about how scalable assays are transforming our approach to cardiac genetics, click the link to view the entire session. Don't miss these expert insights into advancing precision medicine in cardiology! Watch the Full Webinar Here: https://lnkd.in/d5BFGbn3 hashtag #CardiacGenetics #PrecisionMedicine #Webinar #MAVEvidence #ConstantiamBiosciences

Ophthopedia Update:“Congenital Stationary Night Blindness: Structure, Function and Genotype – Phenotype Correlations in a cohort of 122 patients.”: To examine the molecular causes of Schubert-Bornschein (S-B) congenital stationary night blindness (CSNB), clinically characterize in detail, and assess genotype-phenotype correlations for retinal function and structure. #Ophthalmology #Retina #Ophthotwitter

The cumulative evidence available indicates that there can be a prognostic benefit from revascularization in chronic coronary syndrome patients, provided there is significant ischemia, as demonstrated by either imaging or coronary physiology. Trials that have effectively met this criterion consistently demonstrate a reduction in rates of spontaneous myocardial infarction, which holds both prognostic and clinical significance. The prognostic benefit of revascularization in patients with heart failure with reduced ejection fraction remains especially problematic, with a single contemporary trial favouring surgical revascularization. The very recent publication of a trial focused on revascularizing non-flow-limiting "vulnerable" plaques adds further complexity to the field. The ongoing debates surrounding revascularization in chronic coronary syndromes emphasize the importance of personalized strategies. Revascularization, added to the foundational pillar of medical therapy, should be considered, taking into account symptoms, patient preferences, coronary anatomy and physiology, ischemia tests and intra-coronary imaging.

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Check out the calcium flux in these iCell Cardiomyocytes^2 visualized using EarlyTox Cardiotoxicity Dye! Calcium flux governs cardiomyocyte contraction, and assessment of this function is key to cardiotoxicity evaluation of therapeutic candidates. With our new FLIPR system, we can combine our high-content imaging capabilities with functional readouts to gain crucial insights into cardiac physiology, helping you to achieve therapeutic breakthroughs. Our partnership with FUJIFILM Cellular Dynamics enables us to provide our clients with the most advanced, high-quality in vitro assays available. Get in touch with us at https://hubs.ly/Q01ZvpS50 to discuss this cardiomyocyte model or other, more advanced cardiac models, to unlock the full potential of in vitro models for your research needs. #Cardiomyocytes #CalciumFlux #FLIPR #cardiotoxicity #drugdiscovery

#AQVAII study by Simone Biscaglia highlights the power of coronary physiology over conventional angiography in guiding and optimizing PCI, particularly in terms of invasive post-PCI FFR values. Notably, TruePhysio Pressure Microcatheter shines as an efficient and safe method in complex cases. We eagerly await #InsightfulFFR for further outcome evidence on TruePhysio! #TCT2023 #CoronaryPhysiology https://lnkd.in/g-ipFZUm