The Journal of Clinical Investigation

#Cover: Compromised hypothermic cardioprotection in aged donor heart: https://buff.ly/4a07AS4 Authors: Yifan Zhu, Chenyu Jiang, Jian He, Chen He, Xingliang Zhou, Xu Huang, Yi Shen, Liwei Wu, Yongnan Li, Bei Feng, Yi Yan, Jun Li, Hao Zhang, Yiwei Liu #Transplantation

Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis: https://buff.ly/4bweHT7 Authors: Samira Ghorbani, Cenxiao Li, Brian M. Lozinski, Dorsa Moezzi, Charlotte D'Mello, Yifei Dong, Frank Visser, Hongmin Li, Claudia Silva, Mohammadparsa Khakpour, Colin J. Murray, Marie-Ève Tremblay, Mengzhou Xue, V. Wee Yong #Neuroscience

Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation: https://buff.ly/4cCRq3y Authors: Soon-Gook Hong, Julianne W. Ashby, John P. Kennelly, Meigan Wu, Michelle Steel, Eesha Chattopadhyay, Rob Foreman, Peter Tontonoz, Elizabeth J. Tarling, Patric Turowski, Marcus Gallagher-Jones, Julia J. Mack #CellBiology #VascularBiology

The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease: https://buff.ly/3W7heyJ Authors: Siyan Cao, Jose Luis Fachi, Kaiming Ma, Alina Ulezko Antonova, Qianli Wang, Zhangying Cai, Randal J. Kaufman, Matthew A Ciorba, Parakkal Deepak, Marco Colonna #Gastroenterology #Immunology

BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma: https://buff.ly/46ai0yB Authors: Jun Watanabe, Matthew R. Clutter, Michael J. Gullette, Takahiro Sasaki, Eita Uchida, Savneet Kaur, Yan Mo, Kouki Abe, Yukitomo Ishi, Nozomu Takata, Manabu Natsumeda, Samantha Gadd, Zhiguo Zhang, Oren J. Becher, Rintaro Hashizume #Oncology

l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models: https://buff.ly/4cROC1R Authors: Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Madhuparna Pandit, EunHee Shim, Hayley Widden, Juan Liu, Yasaman Heidarian, Nader H. Mahmoudzadeh, Alexander J. Fitt, Devin Absher, Han-Fei Ding, David K. Crossman, William J. Placzek, Jason W. Locasale, Dinesh Rakheja, Jonathan E. McConathy, Rekha Ramachandran, Sejong Bae, Jason M. Tennessen, Sunil Sudarshan #Metabolism #Oncology

#Commentary: Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders: https://buff.ly/4cpe6nK Authors: Sulayman D. Dib-Hajj and Stephen G. Waxman Related article: https://buff.ly/3XV5D7r

#Commentary: Keeping it fresh: ribosomal protein SA sustains sarcomeric function via localized translation: https://buff.ly/3xIEzgO Authors: Abigail Nagle, Michael Regnier, and Jennifer Davis Related article: https://buff.ly/3XTJd6x

The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation: https://buff.ly/4cHAc4k Authors: Xin He, Tinqun Yang, Yao Wei Lu, Gengze Wu, Gang Dai, Qing Ma, Mingming Zhang, Huimin Zhou, Tianxin Long, Youchen Yan, Zhuomin Liang, Chen Liu, William T. Pu, Yugang Dong, Jingsong Ou, Hong Chen, John D. Mably, Jiangui He, Da-Zhi Wang, Zhan-Peng Huang #Cardiology #Development

Peripherally targeted analgesia via AAV-mediated sensory neuron–specific inhibition of multiple pronociceptive sodium channels: https://buff.ly/3XV5D7r Authors: Seung Min Shin, Brandon Itson-Zoske, Fan Fan, Yucheng Xiao, Chensheng Qiu, Theodore R. Cummins, Quinn H. Hogan, Hongwei Yu #Neuroscience #Therapeutics