December 26, 2023, Vol 330, No. 24, Pages 2321-2404

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2023;330(24):e2216169. doi:10.1001/jama.2022.16169

Audio: Prone Positioning During ECMO for ARDS, Fluvoxamine for COVID-19, Hepatitis D Review, and more

Original Investigation

Caring for the Critically Ill Patient

Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial

Matthieu Schmidt, MD; David Hajage, MD; Guillaume Lebreton, MD; et al.

Abstract Full Text

free access

JAMA. 2023;330(24):2343-2353. doi:10.1001/jama.2023.24491

This randomized trial assesses whether prone vs supine positioning decreases the time to successful weaning of extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS).

Editorial
Prone Positioning During Venovenous ECMO for Severe ARDS
Ricardo Teijeiro-Paradis, MD; Niall D. Ferguson, MD, MSc

JAMA

Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19: The ACTIV-6 Randomized Clinical Trial

Thomas G. Stewart, PhD; Paulina A. Rebolledo, MD, MSc; Ahmad Mourad, MD; et al.

Abstract Full Text

free access

JAMA. 2023;330(24):2354-2363. doi:10.1001/jama.2023.23363

This randomized study examines the effect of higher-dose fluvoxamine on time to sustained recovery from mild to moderate COVID-19 or progression to severe disease in nonhospitalized adults.

Editor's Note
Learning From the Success of the ACTIV Platform
Joseph S. Ross, MD, MHS; Preeti Malani, MD, MSJ

JAMA

Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition

Sneha Kannan, MD; Joseph Dov Bruch, PhD; Zirui Song, MD, PhD

Abstract Full Text

free access has active quiz has audio

JAMA. 2023;330(24):2365-2375. doi:10.1001/jama.2023.23147

This observation study examines changes in hospital-acquired adverse events (or conditions) and hospitalization outcomes associated with private equity acquisition among Medicare beneficiaries treated at private equity–acquired hospitals compared with events and outcomes among Medicare beneficiaries treated at control hospitals.

Podcast: Private Equity Acquisition and Hospital-Acquired Adverse Events in the US

Research Letter

Reimbursement to Pharmacies for Generic Drugs by Medicare Part D Sponsors

Inmaculada Hernandez, PharmD, PhD; Nico Gabriel, MA; Anna Kaltenboeck, MA, MBA; et al.

Abstract Full Text

free access

JAMA. 2023;330(24):2390-2392. doi:10.1001/jama.2023.21481

This study evaluates whether organizations that offer Medicare Part D plans (referred to as Part D sponsors) overpay pharmacies for generic drugs.

Pivotal Trial Demographic Representation and Clinical Development Times for Oncology Therapeutics

Alissa K. Wong, BS; Jennifer E. Miller, PhD; Maryam Mooghali, MD, MSc; et al.

Abstract Full Text

free access

JAMA. 2023;330(24):2392-2394. doi:10.1001/jama.2023.21958

This study evaluates whether FDA-approved novel cancer therapeutics supported by pivotal trials with adequate representation of minoritized groups were associated with slower clinical development times than those with inadequate representation.

Viewpoint

Use of Tokens to Unlock Greater Data Sharing in Health Care

Kanan Shah, MD; Debra Patt, MD, MBA, PhD; Samyukta Mullangi, MD, MBA

Abstract Full Text

JAMA. 2023;330(24):2333-2334. doi:10.1001/jama.2023.23720

This Viewpoint discusses the use of privacy-preserving record linkage, a token-based record linkage system, as a promising avenue for building a data infrastructure system that bridges isolated data.

The Unsuccessful Effort to Revise the Uniform Determination of Death Act

Robert D. Truog, MD; David C. Magnus, PhD

Abstract Full Text

JAMA. 2023;330(24):2335-2336. doi:10.1001/jama.2023.24475

This Viewpoint summarizes the major issues that led to the decision to draft a revision of the Uniform Determination of Death Act, the alternatives that were considered, why there was failure to reach consensus, and what this means for the future.

State-Regulated Psychedelics on a Collision Course With FDA

Mason Marks, MD, JD

Abstract Full Text

JAMA. 2023;330(24):2337-2338. doi:10.1001/jama.2023.24762

This Viewpoint examines how US states are reforming legislation to allow access to psychedelics for therapeutic use, but federal laws consider these agents to be Schedule I drugs, and the discordance between state and federal law may create confusion and conflict.

A Piece of My Mind

Pride

David Malebranche, MD, MPH

Abstract Full Text

JAMA. 2023;330(24):2339-2340. doi:10.1001/jama.2023.25077

In this narrative medicine essay, an internal medicine physician, invited to speak at an International AIDS Society plenary session about his HIV work, endures a cool response from his parents upon sharing his HIV status but is met with a standing ovation and cheered by his chosen family and friends after the speech.

Editorial

Prone Positioning During Venovenous ECMO for Severe ARDS

Ricardo Teijeiro-Paradis, MD; Niall D. Ferguson, MD, MSc

Abstract Full Text

JAMA. 2023;330(24):2341-2342. doi:10.1001/jama.2023.22456

Review

Hepatitis D: A Review

Francesco Negro, MD; Anna S. Lok, MD

Abstract Full Text

has active quiz

JAMA. 2023;330(24):2376-2387. doi:10.1001/jama.2023.23242

This review summarizes current evidence regarding diagnosis and treatment of hepatitis D virus.

JAMA Clinical Challenge

A 52-Year-Old With Painful Fingertips

Hideki Oka, MD; Shuji Sumitomo, MD, PhD; Koichiro Ohmura, MD, PhD

Abstract Full Text

has active quiz

JAMA. 2023;330(24):2388-2389. doi:10.1001/jama.2023.22011

A patient had cold, cyanotic fingertips with small ulcerations. Laboratory testing showed leukocytosis, eosinophilia, and elevated D-dimer level; results of tests for antinuclear antibodies, antiphospholipid antibodies, antineutrophil cytoplasmic antibodies against proteinase 3 and myeloperoxidase, and HIV were negative. What is the diagnosis and what would you do next?

Editor's Note

Learning From the Success of the ACTIV Platform

Joseph S. Ross, MD, MHS; Preeti Malani, MD, MSJ

Abstract Full Text

free access

JAMA. 2023;330(24):2363-2364. doi:10.1001/jama.2023.24087

Blood and Hyacinths: The Human Condition in Poetry

Rafael Campo, MD, MA

Abstract Full Text

free access

JAMA. 2023;330(24):2399. doi:10.1001/jama.2023.22008

Medical News & Perspectives

Study Shows Businesses Selling Unapproved Stem Cell Treatments Have Turned to Long COVID

Quinn Eastman, PhD

Abstract Full Text

JAMA. 2023;330(24):2326-2327. doi:10.1001/jama.2023.23897

This Medical News article discusses a new study that identified how business have pivoted marketing of unapproved stem cell and exosome products from COVID-19 to long COVID.

Deciding When It’s Better to Deprescribe Medicines Than to Continue Them

Rita Rubin, MA

Abstract Full Text

has audio

JAMA. 2023;330(24):2328-2330. doi:10.1001/jama.2023.22245

This Medical News article discusses why physicians don’t stop prescribing drugs that may no longer be needed.

Audio: November 2023 Medical News Summary

Medical News in Brief

Sudden Cardiac Deaths Have Decreased Among Young Athletes

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2331. doi:10.1001/jama.2023.23513

HIIT in the Water Might Be Just As Beneficial

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2331. doi:10.1001/jama.2023.24171

Thyroidectomy for Persistent Hashimoto Disease Symptoms

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2331. doi:10.1001/jama.2023.24172

Long-Term ADHD Medications and Cardiovascular Disease Risk

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2331. doi:10.1001/jama.2023.24173

Even Mild Lack of Sleep Might Raise Women’s Diabetes Risk

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2331-2332. doi:10.1001/jama.2023.24174

First At-Home Test for Chlamydia and Gonorrhea Receives FDA Approval

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2332. doi:10.1001/jama.2023.24175

Approaches Decreased EHR Time for Primary Care Clinicians

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2332. doi:10.1001/jama.2023.24176

Caregiving Tied to Mental Health Decline, Including in Younger People

Emily Harris

Abstract Full Text

JAMA. 2023;330(24):2332. doi:10.1001/jama.2023.24177

The Arts and Medicine

Best of Graphic Medicine—The 2023 Graphic Medicine International Collective Awards

Michael J. Green, MD, MS; Kevin Wolf, FSA

Abstract Full Text

JAMA. 2023;330(24):2323-2325. doi:10.1001/jama.2023.24478

This Arts and Medicine feature reviews 4 health-related graphic medicine (comic) projects judged as the best of 2022 by the Graphic Medicine International Collective.

Poetry and Medicine